Successful non-surgical treatment on bilateral spontaneous perirenal giant hematomas in rapidly progressive glomerulonephritis with MPO-ANCA positive

Abstract

Background

Perirenal hematomas are most frequently caused by neoplasm, followed by polyarteritis nodosa (PN), but may also be a rare complication of MPA.

Case Presentation

A 77-year-old woman who presented with rapidly progressive glomerulonephritis, proteinuria, and mononeuropathy multiplex, and was positive for serum myeloperoxidase-anti-neutrophil cytoplasmic antibody, was diagnosed with vasculitis as a probable microscopic polyangiitis (MPA). She developed a spontaneous right-sided perirenal hematoma, along with back pain, on the day of referral to the nephrology unit and a spontaneous left-sided perirenal hematoma ten days later. Treatment with 30 mg/day prednisolone stabilized the hematomas and controlled the progression of probable MPA.

Conclusion

Nephrectomy or embolization is commonly required in patients with perirenal hematoma associated with neoplasm or PN, but radical invasive management may not be necessary in patients with MPA because smaller blood vessels are affected, resulting in less extensive bleeding and normal clotting. Accurate differential diagnosis between MPA and PN is essential to avoid invasive management of perirenal hematomas in patients with MPA. The presence of glomerulonephritis suggests injury to capillary vessels, a characteristic of MPA.

Background

Microscopic polyangiitis (MPA) can be distinguished from polyarteritis nodosa (PN) by the size of affected vessels [1]. MPA is defined as pauci-immune necrotizing vasculitis affecting small vessels, with or without involvement of medium-sized arteries, whereas PN is defined as arteritis of small- and medium-sized arteries without involvement of smaller vessels. However, the clinical manifestations of MPA and PN are similar. Spontaneous perirenal hematoma is not uncommon in patients with PN, but is rare in patients with MPA. Aggressive treatment, including embolization, is sometimes necessary for perirenal hematoma in patients with PN, but the optimum treatment of perirenal hematomas in patients with MPA remains undetermined.

This report describes a patient with vasculitis as a probable MPA and bilateral spontaneous perirenal hematomas, as well as her treatment and outcome.

Case presentation

A 77-year-old woman experienced neck pain, weakness in both arms, and nocturnal fever, followed 1 month later by leg edema and palsy, gait disorder, and pain in the arms. Two months after, she first felt ill; her family doctor diagnosed her with polymyalgia rheumatica and prescribed 10 mg/day prednisolone (PSL). Her renal function was normal that the level of serum creatinine was 0.56 mg/dL and serum blood urea nitrogen (BUN) was 13.9 mg/dL at this time. Her symptoms did not improve, and she was admitted to hospital, where she was diagnosed with infection and administered antibiotics but without effect. Two weeks later, by experiencing progressive deterioration in renal function with an increased serum concentration of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA), she was suspected as MPA and referred to the nephrology unit.

Physical examination showed her body temperature was 37.0 °C, her blood pressure was 160/100 mmHg, and her pulse was 98 beats/min and regular. She had clear consciousness but experienced motor and sensory paresis and pitting edema of the arms and legs. No remarkable findings were observed in her chest and abdomen, although she complained of right back pain. Laboratory tests revealed an increased white blood cell count of 18,200/μL and anemia with 8.6 g/dL hemoglobin. The serum level of creatinine was 1.03 mg/dL. Her blood urea nitrogen (BUN) was elevated at 42 mg/dL, her C-reactive protein (CRP) was 11.43 mg/dL, and her MPO-ANCA was 112.0 EU. Prothrombin time (PT)-INR was 1.91, fibrinogen was 631 mg/dl, and activated partial thromboplastin time (APTT) was 35.2. Urinalysis showed proteinuria, microscopic hematuria, renal tubular epithelial cells, and granular casts (Table 1). Bacterial culture of her pharynx, expectorate, and blood revealed no significant findings.

Table 1 The data of blood and urinary sediment examination at the nephrology referral

Abdominal computed tomography (CT) on the day of referral to the nephrology unit showed a subcapsular hematoma of the right kidney (Fig. 1), which had not been apparent on the last CT image obtained before referral to the unit. We diagnosed her with rapidly progressive glomerulonephritis by an experiencing progressive deterioration in renal function with presence of proteinuria, microscopic hematuria, and cellular casts. A renal biopsy could not be done because of perirenal hematoma, so it was impossible to histologically diagnose. However, she was fulfilled with probable MPA, so we decided to treat her with 30 mg/day of PSL on the ninth day after referral. On day 10, however, she complained of left back pain. Abdominal CT and ultrasonography showed bilateral perirenal hematomas (Fig. 2a, b) and laboratory testing revealed severe anemia with a hemoglobin concentration of 7.2 g/dL. On days 21 and 22, she underwent hemodialysis because her serum concentrations of creatinine (2.70 mg/dL) and BUN (128 mg/dL) had increased; however, her CRP level normalized after she was started on PSL (Fig. 3a, b). After that, her renal function became better and hemodialysis was terminated by decrease in activity of vasculitis. On day 37, the dosage of PSL was reduced to 27.5 mg/day, CT showed that hematoma had not increased in size, and her hemoglobin level was increasing. On day 49, her renal function became better (serum level of creatinine was 1.83 mg/dL and BUN was 50 mg/dL) and she was transferred to the previous hospital.

Fig. 1

Abdominal enhanced CT imaging of a subcapsular hematoma of the right kidney on day 1

Fig. 2

Abdominal CT imaging and ultrasonography on day 10. a Abdominal CT imaging of bilateral perirenal hematomas on day 10. The density area in front of vertebral bone was the intervertebral disc and the iliopsoas muscle. These were also found in another slice of first abdominal CT. b The photograph of ultrasonography of the left kidney on day 10

Fig. 3

Clinical course of the patient. a Change of serum levels of MPO-ANCA and CRP. b Change of serum levels of creatinine and BUN. PSL prednisolone, Hb hemoglobin, CRP C-reactive protein, MPO-ANCA myeloperoxidase-antineutrophil cytoplasmic antibody, Cre creatinine, BUN blood urea nitrogen

Discussion

In this case, we concluded that her experiencing progressive deterioration in renal function was caused by rapidly progressive glomerulonephritis (RPGN) because of the following reasons. There was a finding of nephritis in her urinalysis analysis, and no evidence of postrenal failure in the enhanced abdominal CT. And the fractional excretion of sodium (FENa) and fractional excretion of urea nitrogen (FEUN) proved that her renal failure was not due to a prerenal cause. Moreover, although the worsening of her renal function might be caused by perirenal hematoma, there is a report that renal function was not worse in renal hematoma due to tumor, which did not affect in glomeruli [2]. RPGN and MPO-ANCA-positive suspected MPA in this patient. Definite MPA is diagnosed by the existence of both RPGN and pulmonary complications or definitive histopathological changes in a target organ. Renal biopsy was necessary to diagnose this patient as definite MPA. However, we decided not to perform renal biopsy in this patient whose right kidney had perirenal hematoma at the time of referral to the nephrology unit because renal biopsy in the right kidney had a high risk of induction of retroperitoneum hemorrhage and renal biopsy in the left kidney could not be done caused by equal in single kidney. Then, we diagnosed her as probable MPA and the worsening of her renal function was thought to be caused by probable MPA. Indeed, her renal function became better and hemodialysis could be terminated with the existence of bilateral perirenal hematoma by treatment for probable MPA. Her hematoma was concluded to be induced by probable MPA because an arteriovenous malformation, an aneurysm, or a kidney tumor was not found and enhanced agent was not leaked in other perirenal hematoma in enhanced CT. And the hematoma was not thought to be caused by her coagulation disorder, because her extended PT time was caused by coagulation after drawing blood due to high level of fibrinogen, which was often observed in the inflammatory diseases such as rheumatoid arthritis, and the tendency to bleed such as subcutaneous and nose hemorrhage was not observed.

Spontaneous subcapsular or perirenal hemorrhage is a relatively uncommon complication that often requires additional treatment [3, 4]. A total of 165 patients with this complication were reported between 1985 and 1999 [5]. The most common cause was benign or malignant neoplasm (101 patients, 61 %), followed by vascular diseases (28 patients, 17 %). Of the latter, PN was most often reported (20 patients, 12.1 %), with other vasculitides being rare, including three patients with aneurysm, two with infarction, and one each with arteriovenous malformation (AVM), granulomatosis with polyangiitis (GPA) [4], and portal hypertension [5].

Although rare in patients with PN, spontaneous subcapsular or perirenal hemorrhage is even rarer in patients with MPA. Most reports of this complication in patients with MPA were from Japan, with the incidence being rarer in other countries. The incidence of MPA has been found to vary among countries, being higher than GPA in Asian countries, especially Japan, but very rare in western Europe and America. The clinical features of MPA and PN are similar, but MPA is rarely associated with perirenal hemorrhage. Smaller vessels are affected in MPA than in PN, reducing the volume of bleeding from affected vessels in the former and allowing blood to clot properly. Therefore, the development of a perirenal hematoma in a patient with MPA would require many blood vessels to be simultaneous affected. Furthermore, MPA was often confused with PN, but the two conditions can now be distinguished by the size of the affected vessels. Briefly, small-sized vessels are affected in MPA but not in PN. Thus, the occurrence of proteinuria or glomerular hematuria is evidence for vasculitis in a small-sized glomerular capillary. Indeed, our patient was diagnosed with MPA by the occurrence of proteinuria.

Seventeen of 20 patients with PN treated for spontaneous perirenal hematomas required angioembolization or nephrectomy, whereas the other three were cured following conservative treatment (Table 2) [6–20]. Some of these patients may actually have had MPA. Treatment of spontaneous perirenal hematomas in patients with MPA has not yet been standardized, inasmuch as only seven patients to date, including ours, have been reported with this complication. Two patients underwent angioembolization and the other five, included our patient, were cured with conservative treatment (Table 2) [21]. These indicated that the rate of invasive treatment in PN was 0.85 (17 cases of 20 cases) and that in MPA was 0.28 (two cases of seven cases). There was significant difference between the two groupes (P < 0.01) using the Z test. Thus, invasive treatment was less necessary in patients with MPA than with PN. Moreover, nephritis and renal failure occur more frequently in patients with MPA than PN, considering contrast-induced nephrotoxicity, the careful determination of the angiography would be needed. The rate of involvement of medium-sized arteries, which often require invasive treatment, was found to be 23 % in patients with MPA [22], suggesting that small or microvessels are responsible for perirenal hematoma in patients with MPA, with no need for angioembolization. Invasive treatment in patients with MPA may be necessary for extended continuous bleeding, continuously low blood pressure, progressive anemia, or increased perirenal hemorrhage. Ultrasonography of our patient showed no evidence for increased perirenal hemorrhage. Our findings suggest that spontaneous perirenal hematomas in patients with MPA could be treated conservatively, with no signs of continuous bleeding such as continuous low blood pressure, progressing anemia, and expansion of the hematoma.

Table 2 Description of patients with spontaneous perirenal hematomas and vasculitis

Conclusions

Because perirenal hematomas may develop in patients with MPA, differential diagnosis between MPA and PN is essential to prevent unnecessary invasive methods, such as nephrectomy or angiography, in the former. The presence of glomerulonephritis, which suggests involvement of smaller vessels, may be useful in differentiating between these clinically similar diseases.

Consent

Written informed consent was obtained from the patient’s husband for publication of this case report and any accompanying images because she has died.