Fig. 2

Rho/Rho-kinase. The small GTP-binding protein, Rho, and its downstream effector, Rho-associated kinase (Rho-kinase (ROCK)), are involved in various cellular functions. Under diabetic conditions, the Rho/Rho-kinase pathway is activated. Transcription factors that are involved in inflammatory response (e.g., NF-κB, HIF-1) are regulated by Rho/Rho-kinase