Fig. 2From: In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapyPTA of levofloxacin regimens at different MICs in virtual patients with Gram-positive infection in PIRRT. Early PIRRT is when the first intravenous levofloxacin dose is administered with the commencement of an 8-h daily PIRRT session. Late PIRRT is when the first intravenous levofloxacin dose is administered 16 h before a daily 8-h PIRRT session. The PTA results were the average of PTA on each 24 h period during the initial 72 h therapy in virtual patients with 8-h hemodialysis PIRRT with 5 L/h of dialysate flow rateBack to article page