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Table 4 Factors influencing in-hospital mortality in multivariable logistic regression analysis

From: Blood purification therapy for severe sepsis: a multicenter, observational cohort study in northern Japan

 

Any BPT (N = 127)

Any CRRT (N = 107)

CRRT for renal indications (N = 82)

CRRT for non-renal indications (N = 33)

IRRT (N = 28)

PMX-DHP (N = 42)

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

Odds ratio

1.161

(0.613–2.200)

1.259

(0.642–2.465)

1.579

(0.711–3.506)

0.787

(0.299–2.072)

0.806

(0.551–1.179)

1.491

(0.794–2.798)

SOFA score

1.137

(1.051–1.230)

1.137

(1.051–1.230)

1.139

(1.052–1.232)

1.135

(1.049–1.229)

1.126

(1.040–1.219)

1.134

(1.048–1.227)

Lactate level

1.010

(1.003–1.018)

1.010

(1.003–1.018)

1.011

(1.003–1.018)

1.011

(1.003–1.018)

1.011

(1.003–1.018)

1.009

(1.002–1.017)

AKI stage(Day 1–3)

 0

1.000

–

1.000

–

1.000

–

1.000

–

1.000

–

1.000

–

 1

0.902

(0.404–2.011)

0.898

(0.402–2.006)

0.905

(0.406–2.019)

0.895

(0.401–1.200)

0.881

(0.394–1.966)

0.925

(0.414–2.066)

 2

1.679

(0.783–3.598)

1.690

(0.789–3.620)

1.664

(0.777–3.563)

1.631

(0.759–3.502)

1.671

(0.778–3.587)

1.736

(0.808–3.730)

 3

2.427

(1.260–4.674)

2.337

(1.211–4.507)

1.997

(0.956–4.169)

2.650

(1.517–4.632)

2.799

(1.562–5.011)

2.575

(1.469–4.513)

Primary site of infection

 Lung

1.000

–

1.000

–

1.000

–

1.000

–

1.000

–

1.000

–

 Urinary tract

0.181

(0.075–0.439)

0.184

(0.076–0.442)

0.187

(0.078–0.450)

0.186

(0.077–0.450)

0.173

(0.069–0.430)

0.175

(0.072–0.424)

 Abdomen

0.384

(0.209–0.705)

0.379

(0.205–0.698)

0.376

(0.204–0.694)

0.399

(0.218–0.731)

0.366

( 0.199–0.674)

0.364

(0.197–0.673)

 Others

0.674

(0.372–1.222)

0.668

(0.368–1.212)

0.662

(0.365–1.201)

0.682

(0.378–1.231)

0.693

(0.384–1.249)

0.660

(0.365–1.195)

Mechanical ventilation within 24 h

0.974

(0.559–1.699)

0.975

(0.368–1.212)

0.988

(0.567–1.722)

1.015

(0.581–1.771)

1.024

(0.586–1.789)

0.972

(0.558–1.693)

Inotropes or vasopressors

1.360

(0.746–2.479)

1.343

(0.737–2.449)

1.298

(0.709–2.378)

1.388

(0.760–2.536)

1.441

(0.786–2.640)

1.367

(0.749–2.494)

  1. ORs (95% CI) were estimated using multivariate analysis adjusted for significant covariates in the univariable analysis
  2. Due to collinearity with the APACHE II score, the SOFA score was used for all analyses
  3. Variables used for calculating the SOFA score, i.e., GCS score, MAP, PaO2:FiO2 ratio, and platelet count, were not included in the multivariable model
  4. For all multivariable logistic regression models, the p-values for the Hosmer–Lemeshow test were between 0.165 and 0.254
  5. BPT blood purification therapy, CRRT continuous renal replacement therapy, IRRT intermittent renal replacement therapy, PMX-DHP polymyxin B immobilized fiber column-direct hemoperfusion, OR odds ratio, CI confidence interval, AKI acute kidney injury
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Renal Replacement Therapy

ISSN: 2059-1381

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