Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

Table 5 Recommendations of imipenem dosing regimens for treating Pseudomonas aeruginosa infections with various PD target in critically ill patients undergoing CRRT

PD target	Effluent rates (mL/kg/h)	CVVH (pre-hemofilter dilution)	CVVHD
40% fT > MIC	25 mL/kg/h	500 mg q 8 h or 750 mg q 12 h	500 mg q 8 h
40% fT > MIC	35 mL/kg/h	500 mg q 8 h or 750 mg q 12 h	750 mg q 12 h
40% fT > 4MIC	25 mL/kg/h	750 mg q 6 h	750 mg q 6 h
40% fT > 4MIC	35 mL/kg/h	750 mg q 6 h	750 mg q 6 h
100% fT > MIC	25 mL/kg/h	2500 mg q 8 h	1500 mg q 6 h
100% fT > MIC	35 mL/kg/h	2000 mg q 6 h	2000 mg LD then 1500 mg q 6 h

CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose

ISSN: 2059-1381