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Table 2 Clinical course before and after oral semaglutide administration

From: Oral semaglutide in kidney transplant recipients with metabolic syndrome: three Japanese cases

 

Case 1

Case 2

Case 3

Body weight (Kg)

100.6/96.3

75.4/63.2

79.1/76.4

BMI (Kg/m2)

35.6/34.1

25.0/20.9

29.3/28.5

Abdominal circumference (cm)

114/110

91/80

102/99

SBP (mmHg)

128/121

140/133

124/128

DBP (mmHg)

87/72

72/93

58/63

Cr (mg/dL)

1.63/1.45

2.40/2.24

1.63/1.87

eGFR (ml/min/1.732)

36.6/41.3

22.8/24.4

35.2/30.2

UA (mg/dL)

4.8/4.9

4.1/3.2

3.6/3.8

ALT (IU/L)

30/18

8/6

18/26

γ-GTP (IU/L)

35/29

50/19

27/31

TG (mg/dL)

154/201

308/227

205/123

HbA1c (%)

5.9/5.6

N.A

GA(%) 14.5/13.0

5.5/5.6

UACR (mg/gCr)

73.4/62.0

N.A

UPCR (g/gCr) 1.82/0.89

21.5/36.3

Observation period (months)

12

12

12

  1. Values show data before/after oral semaglutide administration
  2. ALT Alanine aminotransferase, Cr creatinine, γ-GTP γ-glutamyl transpeptidase, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c, N.A. not available, SBP systolic blood pressure, TG triglyceride, UA uric acid, UACR urinary albumin-to-creatinine ratio, UPCR urinary protein-to-creatinine ratio