Intermittent infusion hemodiafiltration is associated with improved survival compared to hemodialysis

Table 2 Comparison of all-cause mortality between the intermittent infusion hemodiafiltration (I-HDF) and hemodialysis (HD) groups using the Cox proportional hazards regression model

Group	Unadjusted			Adjusted for basic factors^a			Adjusted for basic and dialysis-related factors^b			Adjusted for basic, dialysis-related, and nutrition/inflammation-related factors^c
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
HD	1.00	Reference	–	1.00	Reference	–	1.00	Reference	–	1.00	Reference	–
I-HDF	0.84	0.81–0.87	< 0.0001	0.87	0.84–0.91	< 0.0001	0.91	0.87–0.96	0.003	0.94	0.90–0.99	0.016

^aAdjusted for gender, age, duration of dialysis, presence or absence of diabetes, and cardiovascular disease. ^bAdjusted for basic factors and dialysis-related factors, including Kt/V and β₂-microglobulin levels. ^cAdjusted for basic and dialysis-related factors, and nutrition- and inflammation factors, including body mass index, systolic and diastolic blood pressures and heart rate at predialysis, serum albumin, hemoglobin, phosphate, calcium, intact parathyroid hormone, C-reactive protein levels, normalized protein catabolic rate, and % creatinine generation rate. CI, confidence interval; HD, hemodialysis; HR, hazard ratio; I-HDF, intermittent infusion hemodiafiltration

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