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Table 3 Components of the malnutrition inflammation score (MIS)

From: Recent advances in the pathophysiology and management of protein-energy wasting in chronic kidney disease

Malnutrition Inflammation Score

(A) Patient’s related medical history

1- Change in end dialysis dry weight history:

0

1

2

3

No decrease in dry weight or weight loss <0.5 kg

Minor weight loss (≥0.5 kg but <1 kg)

Weight loss more than 1 kg but <5 %

Weight loss >5 %

2- Dietary intake:

0

1

2

3

Good appetite and no deterioration of the dietary intake pattern

Somewhat sub-optimal solid diet intake

Moderate overall decrease to full liquid diet

Hypo-caloric liquid to starvation

3- Gastrointestinal (GI) symptoms:

0

1

2

3

No symptoms with good appetite

Mild symptoms, poor appetite or nauseated occasionally

Occasional vomiting or moderate GI symptoms

Frequent diarrhea or vomiting or severe anorexia

4- Functional capacity (nutritionally related functional impairment):

0

1

2

3

Normal to improved functional capacity, feeling fine

Occasional difficulty with baseline ambulation, or feeling tired frequently

Difficulty with otherwise independent activities (e.g., going to the bathroom)

Bed/chair-ridden, or little to no physical activity

5- Comorbidity including number of years on dialysis:

0

1

2

3

On dialysis less than 1 year and healthy otherwise

Dialyzed for 1–4 years, or mild comorbidity (excluding MCCa)

Dialyzed >4 years, or moderate comorbidity (including one MCCa)

Any severe, multiple comorbidity (2 or more MCCa)

(B) Physical exam (according to SGA criteria):

6- Decrease fat stores or loss of subcutaneous fat (below eyes, triceps, biceps, chest):

0

1

2

3

Normal (no change)

Mild

Moderate

Severe

7- Signs of muscle wasting (temple, clavicle, scapula, ribs, quadriceps, knee, interosseous):

0

1

2

3

Normal (no change)

Mild

Moderate

Severe

(C) Body mass index:

8- Body mass index: BMI = Wt (kg)/Ht2 (m)

0

1

2

3

BMI ≥20 kg/m2

BMI 18–19.99 kg/m2

BMI 16–17.99 kg/m2

BMI <16 kg/m2

(D) Laboratory parameters:

9- Serum albumin:

0

1

2

3

Albumin ≥4.0 g/dL

Albumin 3.5–3.9 g/dL

Albumin 3.0–3.4 g/dL

Albumin <3.0 g/dL

10- Serum TIBC (total iron-binding capacity): ♣

0

1

2

3

TIBC ≥250 mg/dL

TIBC 200–249 mg/dL

TIBC 150–199 mg/dL

TIBC <150 mg/dL

Total score = sum of above 10 components (0–30)

  1. aMCCs (major comorbid conditions) include CHF class III or class IV, full-blown AIDS, severe CAD, moderate to severe COPD, major neurological sequelae, and metastatic malignancies or s/p recent chemotherapy
  2. ♣Suggested equivalent increments for serum transferrin are: > 200 (0), 170-199 (1), 140-169 (2) and < 140 (3) mg/dL