Table 5 Laboratory parameters and vital signs of all patients
Parameters | Start | 4 years after | 8 years after | 4 years mean change ± SEM (95 % CI) | 8 years mean change ± SEM (95 % CI) |
|---|---|---|---|---|---|
P (mg/dL) | 7.8 ± 1.6 | 5.8 ± 1.0*** | 5.3 ± 1.2*** | −2.19 ± 0.29 (−2.80, −1.59)*** | −.51 ± 0.35 (−3.24, −1.79)*** |
Corrected Ca (mg/dL) | 9.3 ± 0.6 | 9.2 ± 0.5 | 9.4 ± 0.6 | −0.11 ± 0.13 (−0.38, 0.16) | 0.11 ± 0.11 (−0.12, 0.34) |
Intact PTH (pg/mL) | 283.1 ± 152.4 | 180.7 ± 126.6*** | 179.1 ± 131.7* | −103.95 ± 27.20 (−160.55, −47.35)*** | −103.45 ± 43.91 (−194.76, −12.14)* |
Na (mEq/L) | 139.2 ± 3.0 | 138.5 ± 2.4 | 138.3 ± 3.3* | −0.89 ± 0.62 (−2.17, 0.38) | −1.20 ± 0.66 (−2.56, 0.16)* |
K (mEq/L) | 5.0 ± 0.7 | 5.4 ± 0.7 | 5.0 ± 0.8 | 0.39 ± 0.10 (0.19, 0.60) | −0.05 ± 0.13 (−0.33, 0.22) |
Cl (mEq/L) | 100.8 ± 3.4 | 102.9 ± 3.6 | 102.0 ± 3.4 | 1.85 ± 0.79 (0.23, 3.47) | 1.07 ± 0.83 (−0.63, 2.78) |
Glucose (mg/dL) | 128.6 ± 51.9 | 123.9 ± 53.3 | 113.9 ± 37.2 | 17.00 ± 23.91 (−37.08, 71.08) | 2.90 ± 8.10 (−15.43, 21.23) |
CRP (mg/dL) | 0.2 ± 0.2 | 0.6 ± 1.3 | 0.6 ± 1.0 | 0.29 ± 0.19 (−0.11, 0.70) | 0.37 ± 0.22 (−0.09, 0.83) |
RBC (×104/μL) | 327 ± 39 | 356 ± 32 | 361 ± 36 | 0.31 ± 0.08 (0.15, 0.47) | 0.34 ± 0.08 (0.18, 0.50) |
WBC (/μL) | 5803 ± 1474 | 6190 ± 2028 | 5891 ± 1977 | 0.44 ± 0.28 (−0.13, 1.01) | 0.16 ± 0.27 (−0.40, 0.71) |
Hb (g/dL) | 10.5 ± 1.1 | 11.2 ± 1.3 | 10.8 ± 1.1 | 0.48 ± 0.26 (−0.04, 1.01) | 0.26 ± 0.26 (−0.28, 0.79) |
Ht (%) | 31.8 ± 3.6 | 34.7 ± 2.6 | 33.9 ± 2.6 | 3.00 ± 0.73 (1.51, 4.51) | 2.06 ± 0.70 (0.62, 3.49) |
Plt (×104/μL) | 19.8 ± 4.4 | 19.7 ± 6.6 | 20.2 ± 6.7 | 0.03 ± 1.04 (−2.21, 2.18) | 2.06 ± 0.70 (0.62, 3.49) |
Serum Alb (g/dL) | 4.0 ± 0.3 | 3.9 ± 0.3* | 3.6 ± 0.3*** | −0.13 ± 0.05 (−0.23, −0.02)* | −0.43 ± 0.06 (−0.56, −0.31)*** |
ALP (U/L) | 237.3 ± 110.1 | 242.6 ± 85.0 | 262.9 ± 95.1 | 2.19 ± 18.32 (−35.54, 39.92) | 10.88 ± 17.59 (−25.34, 47.12) |
LDH (IU/L) | 168.0 ± 30.5 | 173.9 ± 33.5 | 195.5 ± 47.4 | 5.65 ± 6.52 (−7.86, 19.16) | 23.91 ± 7.45 (8.46, 39.37) |
AST (U/L) | 11.7 ± 6.4 | 10.9 ± 4.2 | 17.8 ± 16.5 | −0.85 ± 1.27 (−3.47, 1.76) | 5.85 ± 3.31 (−0.95, 12.65) |
ALT (U/L) | 10.7 ± 5.5 | 10.3 ± 7.2 | 13.7 ± 8.5 | −0.37 ± 1.76 (−3.99, 3.25) | 2.85 ± 1.80 (−0.84, 6.55) |
γ GTP (U/L) | 20.5 ± 12.6 | 26.1 ± 31.5 | 28.2 ± 19.1 | 8.46 ± 6.75 (−5.51, 22.43) | 9.38 ± 3.66 (1.81, 16.94) |
Total bilirubin (mg/dL) | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.04 ± 0.02 (−0.01, 0.09) | 0.05 ± 0.03 (−0.01, 0.12) |
Creatinine (mg/dL) | 12.7 ± 2.0 | 12.3 ± 1.8 | 11.2 ± 2.0*** | −0.30 ± 0.33 (−0.98, 0.37) | −1.40 ± 0.32 (−2.07, −0.74)*** |
Uric acid (mg/dL) | 8.5 ± 1.2 | 8.0 ± 1.5 | 7.7 ± 1.4** | −0.44 ± 0.31 (−1.09, 0.21) | −0.84 ± 0.32 (−1.50, −0.17)** |
BUN (mg/dL) | 72.1 ± 12.0 | 69.6 ± 12.5 | 62.6 ± 16.6** | −0.99 ± 3.02 (−7.21, 5.22) | −9.81 ± 2.90 (−15.78, −3.84)** |
BUN after dialysis (mg/dL) | 23.6 ± 7.0 | 20.0 ± 5.7** | 16.8 ± 6.0*** | −3.85 ± 1.37 (−6.68, −1.02)** | −7.39 ± 1.32 (−10.1, −4.66)*** |
TG (mg/dL) | 132.0 ± 66.0 | 121.8 ± 76.7 | 110.2 ± 46.3 | 10.53 ± 18.02 (−27.33, 48.38) | −5.11 ± 10.69 (−27.57, 17.36) |
Total cholesterol (mg/dL) | 178.0 ± 33.4 | 161.8 ± 37.9 | 171.0 ± 39.2 | −7.56 ± 5.43 (− 19.13, 4.00) | −2.00 ± 8.45 (−20.01, 16.01) |
HDL-C (mg/dL) | 45.5 ± 14.4 | 51.0 ± 14.2 | 53.6 ± 16.9 | 5.16 ± 2.27 (0.40, 9.92) | 6.42 ± 2.29 (1.62, 11.2) |
SBP (mmHg) | 160.2 ± 24.4 | 144.2 ± 21.4*** | 146.2 ± 18.5*** | −19.13 ± 5.19 (−29.89, −8.37)*** | −18.83 ± 4.81 (−28.80, −8.86)*** |
DBP (mmHg) | 88.7 ± 16.5 | 79.6 ± 12.6** | 77.4 ± 13.2*** | −10.26 ± 3.69 (−17.92, −2.6)** | −13.39 ± 2.25 (−18.06, −8.73)*** |
HR (beats/min) | 77.1 ± 12.0 | 74.8 ± 16.9 | 75.0 ± 13.3 | −2.26 ± 2.79 (−8.13, 3.61) | −2.74 ± 3.00 (−9.04, 3.57) |