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Table 5 Laboratory parameters and vital signs of all patients

From: Long-term observational study in Japanese hemodialysis patients who completed a 3-year clinical study of lanthanum carbonate

Parameters Start 4 years after 8 years after 4 years mean change ± SEM (95 % CI) 8 years mean change ± SEM (95 % CI)
P (mg/dL) 7.8 ± 1.6 5.8 ± 1.0*** 5.3 ± 1.2*** −2.19 ± 0.29 (−2.80, −1.59)*** −.51 ± 0.35 (−3.24, −1.79)***
Corrected Ca (mg/dL) 9.3 ± 0.6 9.2 ± 0.5 9.4 ± 0.6 −0.11 ± 0.13 (−0.38, 0.16) 0.11 ± 0.11 (−0.12, 0.34)
Intact PTH (pg/mL) 283.1 ± 152.4 180.7 ± 126.6*** 179.1 ± 131.7* −103.95 ± 27.20 (−160.55, −47.35)*** −103.45 ± 43.91 (−194.76, −12.14)*
Na (mEq/L) 139.2 ± 3.0 138.5 ± 2.4 138.3 ± 3.3* −0.89 ± 0.62 (−2.17, 0.38) −1.20 ± 0.66 (−2.56, 0.16)*
K (mEq/L) 5.0 ± 0.7 5.4 ± 0.7 5.0 ± 0.8 0.39 ± 0.10 (0.19, 0.60) −0.05 ± 0.13 (−0.33, 0.22)
Cl (mEq/L) 100.8 ± 3.4 102.9 ± 3.6 102.0 ± 3.4 1.85 ± 0.79 (0.23, 3.47) 1.07 ± 0.83 (−0.63, 2.78)
Glucose (mg/dL) 128.6 ± 51.9 123.9 ± 53.3 113.9 ± 37.2 17.00 ± 23.91 (−37.08, 71.08) 2.90 ± 8.10 (−15.43, 21.23)
CRP (mg/dL) 0.2 ± 0.2 0.6 ± 1.3 0.6 ± 1.0 0.29 ± 0.19 (−0.11, 0.70) 0.37 ± 0.22 (−0.09, 0.83)
RBC (×104/μL) 327 ± 39 356 ± 32 361 ± 36 0.31 ± 0.08 (0.15, 0.47) 0.34 ± 0.08 (0.18, 0.50)
WBC (/μL) 5803 ± 1474 6190 ± 2028 5891 ± 1977 0.44 ± 0.28 (−0.13, 1.01) 0.16 ± 0.27 (−0.40, 0.71)
Hb (g/dL) 10.5 ± 1.1 11.2 ± 1.3 10.8 ± 1.1 0.48 ± 0.26 (−0.04, 1.01) 0.26 ± 0.26 (−0.28, 0.79)
Ht (%) 31.8 ± 3.6 34.7 ± 2.6 33.9 ± 2.6 3.00 ± 0.73 (1.51, 4.51) 2.06 ± 0.70 (0.62, 3.49)
Plt (×104/μL) 19.8 ± 4.4 19.7 ± 6.6 20.2 ± 6.7 0.03 ± 1.04 (−2.21, 2.18) 2.06 ± 0.70 (0.62, 3.49)
Serum Alb (g/dL) 4.0 ± 0.3 3.9 ± 0.3* 3.6 ± 0.3*** −0.13 ± 0.05 (−0.23, −0.02)* −0.43 ± 0.06 (−0.56, −0.31)***
ALP (U/L) 237.3 ± 110.1 242.6 ± 85.0 262.9 ± 95.1 2.19 ± 18.32 (−35.54, 39.92) 10.88 ± 17.59 (−25.34, 47.12)
LDH (IU/L) 168.0 ± 30.5 173.9 ± 33.5 195.5 ± 47.4 5.65 ± 6.52 (−7.86, 19.16) 23.91 ± 7.45 (8.46, 39.37)
AST (U/L) 11.7 ± 6.4 10.9 ± 4.2 17.8 ± 16.5 −0.85 ± 1.27 (−3.47, 1.76) 5.85 ± 3.31 (−0.95, 12.65)
ALT (U/L) 10.7 ± 5.5 10.3 ± 7.2 13.7 ± 8.5 −0.37 ± 1.76 (−3.99, 3.25) 2.85 ± 1.80 (−0.84, 6.55)
γ GTP (U/L) 20.5 ± 12.6 26.1 ± 31.5 28.2 ± 19.1 8.46 ± 6.75 (−5.51, 22.43) 9.38 ± 3.66 (1.81, 16.94)
Total bilirubin (mg/dL) 0.2 ± 0.1 0.3 ± 0.1 0.3 ± 0.1 0.04 ± 0.02 (−0.01, 0.09) 0.05 ± 0.03 (−0.01, 0.12)
Creatinine (mg/dL) 12.7 ± 2.0 12.3 ± 1.8 11.2 ± 2.0*** −0.30 ± 0.33 (−0.98, 0.37) −1.40 ± 0.32 (−2.07, −0.74)***
Uric acid (mg/dL) 8.5 ± 1.2 8.0 ± 1.5 7.7 ± 1.4** −0.44 ± 0.31 (−1.09, 0.21) −0.84 ± 0.32 (−1.50, −0.17)**
BUN (mg/dL) 72.1 ± 12.0 69.6 ± 12.5 62.6 ± 16.6** −0.99 ± 3.02 (−7.21, 5.22) −9.81 ± 2.90 (−15.78, −3.84)**
BUN after dialysis (mg/dL) 23.6 ± 7.0 20.0 ± 5.7** 16.8 ± 6.0*** −3.85 ± 1.37 (−6.68, −1.02)** −7.39 ± 1.32 (−10.1, −4.66)***
TG (mg/dL) 132.0 ± 66.0 121.8 ± 76.7 110.2 ± 46.3 10.53 ± 18.02 (−27.33, 48.38) −5.11 ± 10.69 (−27.57, 17.36)
Total cholesterol (mg/dL) 178.0 ± 33.4 161.8 ± 37.9 171.0 ± 39.2 −7.56 ± 5.43 (− 19.13, 4.00) −2.00 ± 8.45 (−20.01, 16.01)
HDL-C (mg/dL) 45.5 ± 14.4 51.0 ± 14.2 53.6 ± 16.9 5.16 ± 2.27 (0.40, 9.92) 6.42 ± 2.29 (1.62, 11.2)
SBP (mmHg) 160.2 ± 24.4 144.2 ± 21.4*** 146.2 ± 18.5*** −19.13 ± 5.19 (−29.89, −8.37)*** −18.83 ± 4.81 (−28.80, −8.86)***
DBP (mmHg) 88.7 ± 16.5 79.6 ± 12.6** 77.4 ± 13.2*** −10.26 ± 3.69 (−17.92, −2.6)** −13.39 ± 2.25 (−18.06, −8.73)***
HR (beats/min) 77.1 ± 12.0 74.8 ± 16.9 75.0 ± 13.3 −2.26 ± 2.79 (−8.13, 3.61) −2.74 ± 3.00 (−9.04, 3.57)
  1. Data are given as mean ± standard deviation (n)
  2. CI confidence interval
  3. V.S. At the start, ***P < 0.001, **P < 0.01, *P < 0.05