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Table 2 Pharmacokinetic parameters of arbekacin in study patients

From: Interaction of arbekacin with dialysis membrane

Case

1

2

3

t 1/2 (h)

Off HD

  

38

48

62

  

Polysulfone

 

1.8

7.9

0.9

 

On HD

 

0–1 h

0.7

1.6

.15

  

AN69

1–2 h

1.0

5.7

3.1

   

2–4 h

2.8

n.d.

2.2

 

Off HD

  

5.2

3.7

2.5

  

Polysulfone

 

90

22

170

   

0–1 h

235

105

101

 

On HD

AN69

1–2 h

172

30

50

   

2–4 h

59

n.d.

73

CL of arbekacin by daialyzer (mL/min)

Polysulfone

3.1

2.4

4.9

AN69

186

195

156

Sieving cofficient

Polysulfone

0.99

0.81

.78

AN69

0.05

0.13

0.23

  1. HD hemodialysis, AN69 sulfonated polyacrylonitrile, t 1/2 half-life, CL clearance, n.d. no data