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Table 2 Pharmacokinetic parameters of arbekacin in study patients

From: Interaction of arbekacin with dialysis membrane

Case 1 2 3
t 1/2 (h) Off HD    38 48 62
   Polysulfone   1.8 7.9 0.9
  On HD   0–1 h 0.7 1.6 .15
   AN69 1–2 h 1.0 5.7 3.1
    2–4 h 2.8 n.d. 2.2
  Off HD    5.2 3.7 2.5
   Polysulfone   90 22 170
    0–1 h 235 105 101
  On HD AN69 1–2 h 172 30 50
    2–4 h 59 n.d. 73
CL of arbekacin by daialyzer (mL/min) Polysulfone 3.1 2.4 4.9
AN69 186 195 156
Sieving cofficient Polysulfone 0.99 0.81 .78
AN69 0.05 0.13 0.23
  1. HD hemodialysis, AN69 sulfonated polyacrylonitrile, t 1/2 half-life, CL clearance, n.d. no data