Fig. 3

Time course of peripheral circulation. White square shows the non-CLI group (N = 17). Black triangle represents the CLI group (N = 15). A before the first LDL-A. C at tenth LDL-A. D 1 month after completion of LDL-A treatment. a, b At starting point (point A), ABI showed a significant difference between the CLI and non-CLI groups, while SPP did not. a ABI did not improve by LDL-A treatment. b SPP increased significantly at tenth LDL-A and was sustained until 1 month after completion of LDL-A treatment, though the values decreased after completion of LDL-A treatment in the non-CLI group. All values are expressed as mean ± SD. *P < 0.01. **P < 0.05