Fig. 3

Pathological findings of the second protocol biopsy (second biopsy). a-1 Glomerulus showed mild mesangial matrix expansion and segmental proliferation at the vascular pole. a-2 High magnification of the black-boxed area in a-1 (original magnification, ×400). Inflammatory cells were observed in capillary lumens (arrowhead). b Glomerular immunofluorescent staining (original magnification, ×100). b-1 Global mesangial and capillary granular deposits of C3c. b-2 No apparent IgG deposition was observed. b-3 No apparent IgA deposition was observed. b-4 No apparent IgM deposition was observed. b-5 No apparent C1q deposition was observed. c-1 Dense deposits were observed within the glomerular basement membrane (arrow) and in the mesangium (arrowhead) on electron microscopy (original magnification, ×3000). c-2 Dense deposits were observed within the glomerular basement membrane (arrow) on electron microscopy (original magnification, ×8000)