Fig. 2

Cell therapy using human iPSC-derived renal progenitors ameliorates acute kidney injury in mice. a Time course of blood urea nitrogen (BUN) and plasma creatinine (Cre) levels in acute kidney injury (AKI) mouse models induced by ischemia/reperfusion (I/R) injury that received the renal subcapsular transplantation of human iPSC-derived renal progenitors (iPSC-RPs, triangle), undifferentiated iPSCs (iPSCs, square), or saline (circle). Statistically significant: ***p < 0.001 versus saline, ^†† p < 0.01 versus iPSCs, ^††† p < 0.001 versus iPSCs. b Section images of representative kidney tissue samples from host mice that received an injection of saline (left panel) or the transplantation of iPSC-RPs (right panel). Masson’s trichrome staining images on day 12 after I/R injury and transplantation. Scale bars, 20 μm. Adapted from Toyohara et al. [41]