Table 2 Probability of target attainment of selected ciprofloxacin and levofloxacin dosing regimens for Gram-negative infection with P. aeruginosa a in 5000 virtual patients with 8-h hemodialysis PIRRT at dialysate flow rate of 5 L/h during the initial 72 h
Dosing regimens | Early PIRRTb | Late PIRRTc | ||||||
|---|---|---|---|---|---|---|---|---|
Day 1 PTA (%) | Day 2 PTA (%) | Day 3 PTA (%) | Mean PTA (%) | Day 1 PTA (%) | Day 2 PTA (%) | Day 3 PTA (%) | Mean PTA (%) | |
Ciprofloxacin | ||||||||
200 mg q12h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.3 | 0.6 | 0.1 |
400 mg q12h | 3.9 | 24.3 | 33.4 | 17.3 | 7.8 | 30.0 | 38.0 | 23.8 |
800 mg q12h | 66.6 | 91.2 | 92.5 | 87.9 | 72.5 | 92.6 | 93.7 | 90.1 |
200 mg q8h | 0.3 | 5.8 | 11.2 | 3.5 | 0.4 | 5.5 | 10.5 | 3.5 |
400 mg q8h | 27.7 | 71.0 | 76.2 | 62.2 | 30.1 | 70.3 | 75.6 | 63.3 |
600 mg q8h | 75.4 | 96.1 | 96.9 | 93.9 | 76.3 | 96.2 | 96.9 | 94.3 |
1200 mg LD, then 800 mg q12h | 89.9 | 92.3 | 92.7 | 92.9 | 93.1 | 94.2 | 94.4 | 94.8 |
Levofloxacin | ||||||||
750 mg q24h | 1.7 | 25.4 | 45.9 | 24.4 | 9.9 | 43.5 | 63.5 | 39.0 |
750 mg LD, then 250 mg q24h post-PIRRT | 11.1 | 3.6 | 1.7 | 5.5 | 10.0 | 3.1 | 1.6 | 4.9 |
750 mg LD, then 500 mg q24h post-PIRRT | 27.4 | 32.0 | 35.0 | 31.5 | 10.4 | 20.8 | 28.6 | 20.0 |
750 mg LD, then 750 mg q24h post-PIRRT | 45.3 | 65.5 | 73.9 | 61.5 | 10.9 | 44.1 | 63.1 | 39.4 |
1500 mg LD, then 750 mg q24h post-PIRRT | 83.7 | 84.2 | 83.4 | 83.8 | 66.3 | 74.1 | 77.6 | 72.7 |
1500 mg LD, then 1000 mg q24h post-PIRRT | 89.2 | 93.8 | 95.3 | 92.8 | 67.2 | 84.8 | 91.4 | 81.2 |
2000 mg LD, then 1000 mg q24h post-PIRRT | 96.4 | 97.1 | 96.9 | 96.8 | 87.5 | 92.5 | 94.5 | 91.5 |