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Table 5 Modeled fluoroquinolone clearances and half-lives in PIRRT and comparison to pharmacokinetic data in other types of RRT

From: In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy

Ciprofloxacin

 

PIRRT (present study)

CRRT [30, 31, 36, 37]

EDD

IHD [49]

QEffluent (mL/min)

83.3

17–50b

N/S

500

CLRRT (mL/min)

55.0 ± 13.3a

13.3–41.7b

N/S

57.2

CLOFF-RRT (mL/min)

108.3 ± 48.3a

102–166b

N/S

N/R

t½ ON-RRT (h)

8.2 ± 5.0a

9.4–13.8b

N/S

3.2 ± 0.4a

t½ OFF-RRT (h)

13.9 ± 10.5a

N/A

N/S

5.8 ± 0.9a

Levofloxacin

 

PIRRT (present study)

CRRT [3134]

EDD [27]

IHD [50]

QEffluent (mL/min)

83.3

17–50b

160

600

CLRRT (mL/min)

48.3 + 15.0a

11.0–27.6b

48.8 [25.2–72.5]c

84.4 [61.8–107.6]c

CLOFF-RRT (mL/min)

24.7 + 11.7a

15.0–30.9b

51.0 [49.0–52.8]c

37.0 [12.8–42.7]c

t½ ON-RRT (h)

16.7 + 6.0a

8.3–45.9b

10.3 [10.0–10.6]c

N/R

t½ OFF-RRT (h)

52.8 + 17.0a

N/A

34.5 [21.2–47.7]c

34.4 [28.4–39.3]c

  1. Clearance and half-life data in PIRRT were from on and off 8-h hemodialysis PIRRT
  2. N/A not applicable, N/S not studied, N/R not reported, PIRRT prolonged intermittent renal replacement therapy, CRRT continuous renal replacement therapy, EDD extended daily dialysis, IHD intermittent hemodialysis, Q Effluent effluent flow rate, CL RRT drug clearance by renal replacement therapy, CL OFF-RRT drug clearance off RRT, T ½ ON-RRT half-life during RRT, T ½ OFF-RRT half-life off-RRT
  3. aMean ± SD
  4. bMean ranges reported from the references
  5. cMedian [range]