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Table 5 Modeled fluoroquinolone clearances and half-lives in PIRRT and comparison to pharmacokinetic data in other types of RRT

From: In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy

Ciprofloxacin
  PIRRT (present study) CRRT [30, 31, 36, 37] EDD IHD [49]
QEffluent (mL/min) 83.3 17–50b N/S 500
CLRRT (mL/min) 55.0 ± 13.3a 13.3–41.7b N/S 57.2
CLOFF-RRT (mL/min) 108.3 ± 48.3a 102–166b N/S N/R
t½ ON-RRT (h) 8.2 ± 5.0a 9.4–13.8b N/S 3.2 ± 0.4a
t½ OFF-RRT (h) 13.9 ± 10.5a N/A N/S 5.8 ± 0.9a
Levofloxacin
  PIRRT (present study) CRRT [3134] EDD [27] IHD [50]
QEffluent (mL/min) 83.3 17–50b 160 600
CLRRT (mL/min) 48.3 + 15.0a 11.0–27.6b 48.8 [25.2–72.5]c 84.4 [61.8–107.6]c
CLOFF-RRT (mL/min) 24.7 + 11.7a 15.0–30.9b 51.0 [49.0–52.8]c 37.0 [12.8–42.7]c
t½ ON-RRT (h) 16.7 + 6.0a 8.3–45.9b 10.3 [10.0–10.6]c N/R
t½ OFF-RRT (h) 52.8 + 17.0a N/A 34.5 [21.2–47.7]c 34.4 [28.4–39.3]c
  1. Clearance and half-life data in PIRRT were from on and off 8-h hemodialysis PIRRT
  2. N/A not applicable, N/S not studied, N/R not reported, PIRRT prolonged intermittent renal replacement therapy, CRRT continuous renal replacement therapy, EDD extended daily dialysis, IHD intermittent hemodialysis, Q Effluent effluent flow rate, CL RRT drug clearance by renal replacement therapy, CL OFF-RRT drug clearance off RRT, T ½ ON-RRT half-life during RRT, T ½ OFF-RRT half-life off-RRT
  3. aMean ± SD
  4. bMean ranges reported from the references
  5. cMedian [range]