Fig. 3

Plasma concentrations of topiroxostat and its metabolites after repeated administration of 20 mg twice per day of topiroxostat. There were no significant differences between the concentrations of topiroxostat and its three metabolites at weeks 4, 12, 26, and 52 (paired t test vs. 4 weeks, after Bonferroni corrections). (n = 20, week 4; n = 19, weeks 19, 26, and 52). Mean ± SD