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Table 2 Biochemical test results at the baseline and during the follow-up

From: Effects, safety, and plasma levels of topiroxostat and its metabolites in patients receiving hemodialysis

Parameter Baseline Week 4 Week 12 Week 26 Week 52
Number of participants 20 20 19 19 19
BUN (mmol/L) 25.1 ± 5.2 24.3 ± 5.4 20.8 ± 6.9* 20.8 ± 4.9* 23.5 ± 5.2
Creatinine (μmol/L) 1105.4 ± 244.4 1079.2 ± 210.6 1003.8 ± 286.9 1030.2 ± 281.2* 1018.7 ± 251.8*
Total protein (g/L) 63.2 ± 5.0 64.7 ± 5.4 61.3 ± 4.9 62.4 ± 7.0 63.2 ± 5.4
Albumin (g/L) 37.6 ± 3.1 37.3 ± 4.6 35.8 ± 4.6 36.7 ± 5.3 36.1 ± 3.9
AST (IU/L) 12.6 ± 7.3 11.4 ± 5.2 10.5 ± 4.4 12.1 ± 5.9 11.5 ± 5.3
ALT (IU/L) 10.8 ± 6.3 9.8 ± 4.0 9.2 ± 3.5 10.5 ± 3.0 9.7 ± 5.6
ALP (IU/L) 243.8 ± 94.8 218.9 ± 69.7 213.6 ± 92.4 243.1 ± 133.3 224.9 ± 78.7
Total bilirubin (μmol/L) 4.4 ± 1.5 4.5 ± 1.7 4.4 ± 1.8 4.8 ± 2.3 4.5 ± 1.3
LDH (IU/L) 186.6 ± 25.5 185.0 ± 29.1 184.1 ± 31.9 191.8 ± 40.0 181.7 ± 27.1
Total cholesterol (mmol/L) 4.273 ± 0.710 4.439 ± 0.900 4.266 ± 0.797 4.539 ± 0.918 4.241 ± 1.159
Triglycerides (mmol/L) 1.214 ± 0.414 1.096 ± 0.281 1.036 ± 0.333 1.149 ± 0.386 1.213 ± 0.635
HDL cholesterol (mmol/L) 1.24 ± 0.39 1.38 ± 0.49 1.41 ± 0.52 1.52 ± 0.72 1.30 ± 0.44
LDL cholesterol (mmol/L) 2.41 ± 0.41 2.56 ± 0.66 2.45 ± 0.63 2.53 ± 0.74 2.44 ± 0.89
  1. BUN blood urea nitrogen, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, LDH lactate dehydrogenase
  2. *p < 0.05 (paired t test vs. baseline, after Bonferroni corrections). Mean ± SD