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Table 3 Clearances of topiroxostat and its metabolites by a dialyzer by use of an arterio-venous method

From: Effects, safety, and plasma levels of topiroxostat and its metabolites in patients receiving hemodialysis

  Pre-dialyzer concentration Post-dialyzer concentration Clearance (mL/min)
Topiroxostat(μmol/L) 0.269 ± 0.164 0.216 ± 0.166 55.9 ± 31.1
N-Oxide (μmol/L) 0.0812 ± 0.0277 0.0317 ± 0.0190 143.9 ± 37.0
N 1-Glucuronide (μmol/L) 3.21 ± 1.00 0.81 ± 0.64 179.0 ± 41.1
N 2-Glucuronide (μmol/L) 0.853 ± 0.412 0.144 ± 0.121 192.9 ± 37.0
Albumin (g/L) 32.8 ± 5.2 32.5 ± 5.1 2.3 ± 6.7
BUN (mmol/L) 18.8 ± 7.6 1.3 ± 1.0 217.2 ± 27.8
Creatinine (μmol/L) 769.8 ± 164.4 169.4 ± 40.7 179.4 ± 20.4
Serum uric acid (μmol/L) 224.0 ± 66.4 46.6 ± 17.4 184.0 ± 26.2
  1. Mean ± SD. n = 6