Table 3 Clearances of topiroxostat and its metabolites by a dialyzer by use of an arterio-venous method
Pre-dialyzer concentration | Post-dialyzer concentration | Clearance (mL/min) | |
|---|---|---|---|
Topiroxostat(μmol/L) | 0.269 ± 0.164 | 0.216 ± 0.166 | 55.9 ± 31.1 |
N-Oxide (μmol/L) | 0.0812 ± 0.0277 | 0.0317 ± 0.0190 | 143.9 ± 37.0 |
N 1-Glucuronide (μmol/L) | 3.21 ± 1.00 | 0.81 ± 0.64 | 179.0 ± 41.1 |
N 2-Glucuronide (μmol/L) | 0.853 ± 0.412 | 0.144 ± 0.121 | 192.9 ± 37.0 |
Albumin (g/L) | 32.8 ± 5.2 | 32.5 ± 5.1 | 2.3 ± 6.7 |
BUN (mmol/L) | 18.8 ± 7.6 | 1.3 ± 1.0 | 217.2 ± 27.8 |
Creatinine (μmol/L) | 769.8 ± 164.4 | 169.4 ± 40.7 | 179.4 ± 20.4 |
Serum uric acid (μmol/L) | 224.0 ± 66.4 | 46.6 ± 17.4 | 184.0 ± 26.2 |