| |
Unadjusted
|
Model 1
|
Model 2
|
|---|
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
|---|
|
All-cause mortality
|
|
Q1
|
1 (Reference)
|
<0.001†
|
1 (Reference)
|
<0.001†
|
1 (Reference)
|
0.003†
|
|
Q2
|
1.23 (0.52 to 2.93)
| |
0.95 (0.37 to 2.49)
| |
0.71 (0.26 to 1.96)
| |
|
Q3
|
3.06 (1.43 to 6.52)
| |
2.24 (0.98 to 5.16)
| |
1.94 (0.83 to 4.58)
| |
|
Q4
|
4.37 (2.10 to 9.10)
| |
4.37 (1.94 to 9.84)
| |
3.12 (1.26 to 7.74)
| |
|
per 104 cells/μL
|
1.29 (1.18 to 1.42)
|
<0.001
|
1.37 (1.23 to 1.53)
|
<0.001
|
1.33 (1.17 to 1.51)
|
<0.001
|
|
Cardiovascular mortality
|
|
Q1
|
1 (Reference)
|
<0.001†
|
1 (Reference)
|
0.005†
|
1 (Reference)
|
0.03†
|
|
Q2
|
1.86 (0.56 to 6.19)
| |
1.91 (0.47 to 7.62)
| |
1.59 (0.37 to 6.79)
| |
|
Q3
|
5.59 (1.92 to 16.27)
|
4.97 (1.41 to 17.46)
|
4.18 (1.14 to 15.25)
|
|
Q4
|
5.67 (1.94 to 16.59)
|
6.57 (1.85 to 23.34)
|
4.93 (1.24 to 19.56)
|
|
per 104 cells/μL
|
1.28 (1.14 to 1.43)
|
<0.001
|
1.37 (1.19 to 1.56)
|
<0.001
|
1.38 (1.17 to 1.63)
|
<0.001
|
- Patients were quartiled according to reticulocyte count. Q1, ≤30.1 × 103 cells/μL; Q2, 30.2 to 39.4 × 103 cells/μL; Q3, 39.6 to 53.6 × 103 cells/μL; Q4, ≥53.7 × 103 cells. Model 1 is adjusted for age, sex, diabetic nephropathy, duration of dialysis, interdialysis weight gain, smoking status, vascular disease history, use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, systolic blood pressure, diastolic blood pressure, and weekly dose of recombinant human erythropoietin. Model 2 is adjusted for model 1 covariates and hemoglobin, white blood cell, platelet count, transferrin saturation, ferritin, phosphorus inorganic, creatinine, albumin, and C-reactive protein
- Note: HR hazard ratio, CI confidence interval
-
†
p for linear trend
