Inducers | Inhibitors | Target for treatment |
---|
Aging | Fetuin A | Phosphate |
Phosphate/calcium | MGP | Calcium |
Inflammation | Pyrophosphate | Intact PTH |
Aldosterone | Osteopontin | Vitamin D |
Warfarin use | Osteoprotegerin | Vitamin K |
AGEs/diabetes | BMP7 | Acidosis |
BMP2/4 | Adiponectin | Inflammation |
Leptin | Collagen IV | Dialysate |
oxLDL | Â | Â |
Collagen I/fibronectin | Â | Â |
High blood pressure | Â | Â |
- Inducers and inhibitors for vascular calcifications are listed. As shown in the table, several factors associate the pathophysiology of vascular calcification. Several inhibitor systems exist in the human body, and it might mean the importance to protect from ectopic vascular calcification. If the inhibitory system would fail, serious complication might occur. Treatment target which we can intervene are also listed
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Abbreviations: AGEs advanced glycation end products, BMP bone morphogenic protein, LDL low-density lipoprotein, MGP matrix Gla protein, PTH; parathyroid hormone