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Table 1 Associating factors for vascular calcification in hemodialysis patients

From: Impact of vascular calcification on cardiovascular mortality in hemodialysis patients: clinical significance, mechanisms and possible strategies for treatment

Inducers

Inhibitors

Target for treatment

Aging

Fetuin A

Phosphate

Phosphate/calcium

MGP

Calcium

Inflammation

Pyrophosphate

Intact PTH

Aldosterone

Osteopontin

Vitamin D

Warfarin use

Osteoprotegerin

Vitamin K

AGEs/diabetes

BMP7

Acidosis

BMP2/4

Adiponectin

Inflammation

Leptin

Collagen IV

Dialysate

oxLDL

  

Collagen I/fibronectin

  

High blood pressure

  
  1. Inducers and inhibitors for vascular calcifications are listed. As shown in the table, several factors associate the pathophysiology of vascular calcification. Several inhibitor systems exist in the human body, and it might mean the importance to protect from ectopic vascular calcification. If the inhibitory system would fail, serious complication might occur. Treatment target which we can intervene are also listed
  2. Abbreviations: AGEs advanced glycation end products, BMP bone morphogenic protein, LDL low-density lipoprotein, MGP matrix Gla protein, PTH; parathyroid hormone