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Table 3 Comparisons of demographic date at CRRT initiation and outcomes in early and late groups

From: The optimal timing of continuous renal replacement therapy according to the modified RIFLE classification in critically ill patients with acute kidney injury: a retrospective observational study

 

All patients

Early group

Late group

P value

(n = 189)

(n = 52)

(n = 137)

 

Demographic data at CRRT initiation

 Mechanical ventilation, n (%)

150 (79)

45 (87)

105(77)

0.16

 Vasopressor, n (%)

101 (53)

26 (50)

75 (55)

0.63

 Diuretic use, n (%)

70 (37)

21 (40)

49 (36)

0.61

 Creatinine (mg/dl), median (IQR)

2.7 (1.9–4.0)

1.8 (1.2–3.0)

2.8 (2.2–4.2)

<0.001

 eGFR (ml/min/1.73 m2)

18 (12–28)

30 (15–44)

18 (11–25)

<0.001

 BUN (mg/dl), median (IQR)

50 (31–72)

37 (29–59)

54 (34–87)

<0.001

 Urine Output (ml/h), median (IQR)

19 (8–35)

21 (10–46)

17 (7.6–33)

0.09

 Bilirubin (mg/dl), median (IQR)

1.0 (0.6–2.3)

1.8 (0.7–3.7)

1.0 (0.6–2.5)

0.83

 Platelets (cells/103), median (IQR)

112 (63–188)

107 (65–159)

118 (62–194)

0.84

 Albumin (g/dl), median (IQR)

2.5 (2.0–3.1)

2.5 (2.1–3.1)

2.5 (2.0–3.1)

0.87

 PiO2/FiO2, (Torr), median (IQR)

181 (117–293)

198 (139–338)

200 (119–329)

0.16

 Glasgow Coma Scale, median (IQR)

13 (6–15)

13 (6–15)

13 (6–15)

0.69

Factors contributing to AKI

 Sepsis, n (%)

74 (39)

21 (40)

53 (39)

0.87

 Cardiogenic shock, n (%)

59 (31)

20 (39)

39 (29)

0.22

 Drug-induced AKI, n (%)

4 (2)

1 (2)

3 (2)

1

 Hypovolemia, n (%)

15 (8)

1 (2)

14 (10)

0.07

 Post-operative, n (%)

35 (19)

10 (19)

25 (18)

0.87

 Post-renal failure, n (%)

1 (2)

0 (0)

1 (1)

1

 Others, n (%)

7 (4)

2 (4)

5 (4)

1

Outcomes

 Duration of CRRT (day), median (IQR)

3 (1–8)

3 (1–6)

3 (1–9)

0.3

 ICU length of stay (day), median (IQR)

10 (4–18)

8(3–16)

10 (5–18)

0.34

 Post-CRRT hospital length of stay (day), median (IQR)

11 (1–32)

13 (1–32)

11 (1–32)

0.81

 Hospital length of stay (days), median, median (IQR)

26 (13–57)

29 (14–43)

26 (11–62)

0.81

 Time interval from ICU admission to CRRT initiation (day), median (IQR)

0.8 (0.1–1.9)

0.8 (0.2–2.0)

0.8 (0.1–1.9)

0.89

 ICU mortality, n (%)

86 (47)

26 (50)

60 (44)

0.51

 Hospital mortality, n (%)

101 (53)

33 (64)

68 (50)

0.1

  1. Others: hyperkalemia (two patients), acute pancreatitis, Goodpasture syndrome, mixed acidosis, acute renal stroke, and catastrophic anti-phospholipid syndrome
  2. Abbreviations: CRRT continuous renal replacement therapy, IQR interquartile range, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, AKI acute kidney injury, ICU intensive care unit