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Table 3 Comparisons of demographic date at CRRT initiation and outcomes in early and late groups

From: The optimal timing of continuous renal replacement therapy according to the modified RIFLE classification in critically ill patients with acute kidney injury: a retrospective observational study

  All patients Early group Late group P value
(n = 189) (n = 52) (n = 137)  
Demographic data at CRRT initiation
 Mechanical ventilation, n (%) 150 (79) 45 (87) 105(77) 0.16
 Vasopressor, n (%) 101 (53) 26 (50) 75 (55) 0.63
 Diuretic use, n (%) 70 (37) 21 (40) 49 (36) 0.61
 Creatinine (mg/dl), median (IQR) 2.7 (1.9–4.0) 1.8 (1.2–3.0) 2.8 (2.2–4.2) <0.001
 eGFR (ml/min/1.73 m2) 18 (12–28) 30 (15–44) 18 (11–25) <0.001
 BUN (mg/dl), median (IQR) 50 (31–72) 37 (29–59) 54 (34–87) <0.001
 Urine Output (ml/h), median (IQR) 19 (8–35) 21 (10–46) 17 (7.6–33) 0.09
 Bilirubin (mg/dl), median (IQR) 1.0 (0.6–2.3) 1.8 (0.7–3.7) 1.0 (0.6–2.5) 0.83
 Platelets (cells/103), median (IQR) 112 (63–188) 107 (65–159) 118 (62–194) 0.84
 Albumin (g/dl), median (IQR) 2.5 (2.0–3.1) 2.5 (2.1–3.1) 2.5 (2.0–3.1) 0.87
 PiO2/FiO2, (Torr), median (IQR) 181 (117–293) 198 (139–338) 200 (119–329) 0.16
 Glasgow Coma Scale, median (IQR) 13 (6–15) 13 (6–15) 13 (6–15) 0.69
Factors contributing to AKI
 Sepsis, n (%) 74 (39) 21 (40) 53 (39) 0.87
 Cardiogenic shock, n (%) 59 (31) 20 (39) 39 (29) 0.22
 Drug-induced AKI, n (%) 4 (2) 1 (2) 3 (2) 1
 Hypovolemia, n (%) 15 (8) 1 (2) 14 (10) 0.07
 Post-operative, n (%) 35 (19) 10 (19) 25 (18) 0.87
 Post-renal failure, n (%) 1 (2) 0 (0) 1 (1) 1
 Others, n (%) 7 (4) 2 (4) 5 (4) 1
Outcomes
 Duration of CRRT (day), median (IQR) 3 (1–8) 3 (1–6) 3 (1–9) 0.3
 ICU length of stay (day), median (IQR) 10 (4–18) 8(3–16) 10 (5–18) 0.34
 Post-CRRT hospital length of stay (day), median (IQR) 11 (1–32) 13 (1–32) 11 (1–32) 0.81
 Hospital length of stay (days), median, median (IQR) 26 (13–57) 29 (14–43) 26 (11–62) 0.81
 Time interval from ICU admission to CRRT initiation (day), median (IQR) 0.8 (0.1–1.9) 0.8 (0.2–2.0) 0.8 (0.1–1.9) 0.89
 ICU mortality, n (%) 86 (47) 26 (50) 60 (44) 0.51
 Hospital mortality, n (%) 101 (53) 33 (64) 68 (50) 0.1
  1. Others: hyperkalemia (two patients), acute pancreatitis, Goodpasture syndrome, mixed acidosis, acute renal stroke, and catastrophic anti-phospholipid syndrome
  2. Abbreviations: CRRT continuous renal replacement therapy, IQR interquartile range, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, AKI acute kidney injury, ICU intensive care unit