Presepsin is a potent biomarker for diagnosing skin wound infection in hemodialysis patients compared to white blood cell count, high-sensitivity C-reactive protein, procalcitonin, and soluble CD14

Table 1 Comparison of characteristics and infection biomarkers between the localized infection group and the no infection group

	All patients		Patients examined for all biomarkers including sCD14 and PCT
Group	Localized infection	No infection	Localized infection	No infection
Number	29	20	12	8
Age, years	72 (66–77)	78 (74–83)	73 (65–78)	78 (72–84)
Male, %	48.3	55.0	66.7	62.5
WBC, μL	5700 (4333–7100)	5250 (4475–6000)	5800 (4675–6735)	5450 (4475–5750)
hsCRP, mg/dL	1.26 (0.71–2.24)*	0.23 (0.10–1.22)	1.30 (0.50–2.16)	0.17 (0.11–0.74)
Presepsin, pg/mL	3370 (2240–4480)**	1510 (1205–1810)	3330 (2515–3990)*	1560 (1488–1973)
sCD14, ng/mL			2278 (1969–2906)	2417 (2226–2732)
PCT, ng/mL			0.23 (0.20–0.27)	0.25 (0.21–0.28)

Data were presented as the median (interquartile range, IQR). Statistics were analyzed using the Mann-Whitney U test. A blood analysis was performed to determine the WBC count, and the hsCRP and presepsin levels of 49 HD patients who were enrolled in 2014/1/1–2015/3/31 (shown as “all patients”). sCD14 and PCT were also measured in the 20 HD patients enrolled after 2015/1/1 (shown as “patients examined for all biomarkers including sCD14 and PCT”)
*P < 0.05, **P < 0.01 vs. the no infection group

ISSN: 2059-1381