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Table 2 Previously reported 22 cases of trimethoprim-sulfamethoxazole-induced hypoglycemia and the present case

From: Severe hypoglycemia during pneumocystis pneumonia treatment associated with trimethoprim–sulfamethoxazole use in a patient on peritoneal dialysis

Case number

Reported year

[Reference]

Age/sex

Indication for TMP/SMX

Underlying disease

Prednisolone use (dosage)

Serum creatinine level (mg/dL)

Dose of SMX (mg/day)

Route of administration

Duration (days)

Lowest serum glucose level (mg/dL)

Highest serum insulin level (μU/mL)

Case 1

1983

[10]

65/F

UTI

CRF, CHF

N/A

6.1

1600

p.o.

10

27

36

Case 2

1984

[11]

63/M

Septic arthritis

ESRD on HD

N/A

11

4800

p.o.

5

26

N/A

Case 3

1984

[12]

85/F

UTI

CRF, DM, PD

N/A

N/A

1600

p.o.

7

24

3

Case 4

1984

[12]

74/F

UTI

CRF, DM

N/A

8.2

1600

p.o.

N/A

12

6

Case 5

1987

[7]

62/M

PCP

CRF, MM

N/A

3.3

4800

N/A

7

20

34.5

Case 6

1988

[13]

88/F

PCP

N/A

N/A

1.2

1600

p.o.

4

33

N/A

Case 7

1988

[14]

64/M

PCP

ESRD on HD

60 mg/day p.o.

10

7680

i.v.

2

33

N/A

Case 8

1988

[15]

34/M

PCP

AIDS, Hepatitis B

N/A

N/A

N/A

N/A

6

22

12

Case 9

1992

[16]

19/F

N/A

ESRD on PD

N/A

N/A

1600

p.o.

1

17

N/A

Case 10

1992

[8]

72/M

Prophylaxis

Lymphoma

N/A

0.7

N/A

N/A

N/A

14

N/A

Case 11

1993

[17]

36/M

PCP

Renal transplant

N/A

2.7

4800/9600

i.v./ p.o.

62

33

N/A

Case 12

1997

[18]

73/M

Pneumonia

ARF

N/A

5.1

6000/3000

i.v./i.v.

69

22

N/A

Case 13

2000

[19]

91/F

UTI

N/A

N/A

1.7

3200

p.o.

7

34

N/A

Case 14

2001

[20]

41/M

PCP

AIDS, Hepatitis C

N/A

1.36

6400

p.o.

10

18

30.2

Case 15

2006

[6]

46/M

PCP

AIDS

N/A

1.97

6400

p.o.

18

29

20.6

Case 16

2008

[21]

76/M

Endophthalmitis

N/A

N/A

2.1

75 mg/kg/day

N/A

11

20

N/A

Case 17

2010

[4]

44/F

PCP

AIDS

80 mg/day i.v.

0.8

6400

i.v.

7

59

84

Case 18

2010

[4]

24/M

PCP

AIDS

80 mg/day i.v.

0.8

4800

i.v.

20

40

80

Case 19

2012

[22]

56/F

PCP

ESRD, Renal transplant

5 mg/day p.o.

N/A

N/A

N/A

5

31

N/A

Case 20

2012

[23]

83/M

Prophylaxis

Lymphoma

N/A

1.72

1600 (2 times a week)

p.o.

N/A

25

N/A

Case 21

2013

[24]

52/F

Prophylaxis

EGPA

40 mg/day p.o.

N/A

400

p.o.

N/A

31

42.6

Case 22

2017

[25]

69/M

Pneumonia

MPA, AKI, FN

Yes (N/A)

2.62

4800

N/A

4

28.8

99.4

Case 23

2017

The present case

54/F

PCP

RA, ESRD on PD

3 mg/day p.o.

8.96

1600

p.o.

10

15

69.4

  1. F female, M male, TMP/SMX trimethoprim/sulfamethoxazole, UTI urinary tract infection, PCP Pneumocystis jirovecii pneumonia, N/A not available, CRF chronic renal failure, CHF congestive heart failure, ESRD end-stage renal disease, HD hemodialysis, DM diabetes mellitus, PD Parkinson’s disease, MM multiple myeloma, AIDS acquired immune deficiency syndrome, PD peritoneal dialysis, ARF acute renal failure, EGPA eosinophilic granulomatosis with polyangiitis, MPA microscopic polyangiitis, AKI acute kidney injury, FN febrile neutropenia, RA rheumatoid arthritis, p.o. per os, i.v. intravenous
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