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Table 2 Previously reported 22 cases of trimethoprim-sulfamethoxazole-induced hypoglycemia and the present case

From: Severe hypoglycemia during pneumocystis pneumonia treatment associated with trimethoprim–sulfamethoxazole use in a patient on peritoneal dialysis

Case number Reported year [Reference] Age/sex Indication for TMP/SMX Underlying disease Prednisolone use (dosage) Serum creatinine level (mg/dL) Dose of SMX (mg/day) Route of administration Duration (days) Lowest serum glucose level (mg/dL) Highest serum insulin level (μU/mL)
Case 1 1983 [10] 65/F UTI CRF, CHF N/A 6.1 1600 p.o. 10 27 36
Case 2 1984 [11] 63/M Septic arthritis ESRD on HD N/A 11 4800 p.o. 5 26 N/A
Case 3 1984 [12] 85/F UTI CRF, DM, PD N/A N/A 1600 p.o. 7 24 3
Case 4 1984 [12] 74/F UTI CRF, DM N/A 8.2 1600 p.o. N/A 12 6
Case 5 1987 [7] 62/M PCP CRF, MM N/A 3.3 4800 N/A 7 20 34.5
Case 6 1988 [13] 88/F PCP N/A N/A 1.2 1600 p.o. 4 33 N/A
Case 7 1988 [14] 64/M PCP ESRD on HD 60 mg/day p.o. 10 7680 i.v. 2 33 N/A
Case 8 1988 [15] 34/M PCP AIDS, Hepatitis B N/A N/A N/A N/A 6 22 12
Case 9 1992 [16] 19/F N/A ESRD on PD N/A N/A 1600 p.o. 1 17 N/A
Case 10 1992 [8] 72/M Prophylaxis Lymphoma N/A 0.7 N/A N/A N/A 14 N/A
Case 11 1993 [17] 36/M PCP Renal transplant N/A 2.7 4800/9600 i.v./ p.o. 62 33 N/A
Case 12 1997 [18] 73/M Pneumonia ARF N/A 5.1 6000/3000 i.v./i.v. 69 22 N/A
Case 13 2000 [19] 91/F UTI N/A N/A 1.7 3200 p.o. 7 34 N/A
Case 14 2001 [20] 41/M PCP AIDS, Hepatitis C N/A 1.36 6400 p.o. 10 18 30.2
Case 15 2006 [6] 46/M PCP AIDS N/A 1.97 6400 p.o. 18 29 20.6
Case 16 2008 [21] 76/M Endophthalmitis N/A N/A 2.1 75 mg/kg/day N/A 11 20 N/A
Case 17 2010 [4] 44/F PCP AIDS 80 mg/day i.v. 0.8 6400 i.v. 7 59 84
Case 18 2010 [4] 24/M PCP AIDS 80 mg/day i.v. 0.8 4800 i.v. 20 40 80
Case 19 2012 [22] 56/F PCP ESRD, Renal transplant 5 mg/day p.o. N/A N/A N/A 5 31 N/A
Case 20 2012 [23] 83/M Prophylaxis Lymphoma N/A 1.72 1600 (2 times a week) p.o. N/A 25 N/A
Case 21 2013 [24] 52/F Prophylaxis EGPA 40 mg/day p.o. N/A 400 p.o. N/A 31 42.6
Case 22 2017 [25] 69/M Pneumonia MPA, AKI, FN Yes (N/A) 2.62 4800 N/A 4 28.8 99.4
Case 23 2017 The present case 54/F PCP RA, ESRD on PD 3 mg/day p.o. 8.96 1600 p.o. 10 15 69.4
  1. F female, M male, TMP/SMX trimethoprim/sulfamethoxazole, UTI urinary tract infection, PCP Pneumocystis jirovecii pneumonia, N/A not available, CRF chronic renal failure, CHF congestive heart failure, ESRD end-stage renal disease, HD hemodialysis, DM diabetes mellitus, PD Parkinson’s disease, MM multiple myeloma, AIDS acquired immune deficiency syndrome, PD peritoneal dialysis, ARF acute renal failure, EGPA eosinophilic granulomatosis with polyangiitis, MPA microscopic polyangiitis, AKI acute kidney injury, FN febrile neutropenia, RA rheumatoid arthritis, p.o. per os, i.v. intravenous