|
Case number
|
Reported year
|
[Reference]
|
Age/sex
|
Indication for TMP/SMX
|
Underlying disease
|
Prednisolone use (dosage)
|
Serum creatinine level (mg/dL)
|
Dose of SMX (mg/day)
|
Route of administration
|
Duration (days)
|
Lowest serum glucose level (mg/dL)
|
Highest serum insulin level (μU/mL)
|
|---|
|
Case 1
|
1983
|
[10]
|
65/F
|
UTI
|
CRF, CHF
|
N/A
|
6.1
|
1600
|
p.o.
|
10
|
27
|
36
|
|
Case 2
|
1984
|
[11]
|
63/M
|
Septic arthritis
|
ESRD on HD
|
N/A
|
11
|
4800
|
p.o.
|
5
|
26
|
N/A
|
|
Case 3
|
1984
|
[12]
|
85/F
|
UTI
|
CRF, DM, PD
|
N/A
|
N/A
|
1600
|
p.o.
|
7
|
24
|
3
|
|
Case 4
|
1984
|
[12]
|
74/F
|
UTI
|
CRF, DM
|
N/A
|
8.2
|
1600
|
p.o.
|
N/A
|
12
|
6
|
|
Case 5
|
1987
|
[7]
|
62/M
|
PCP
|
CRF, MM
|
N/A
|
3.3
|
4800
|
N/A
|
7
|
20
|
34.5
|
|
Case 6
|
1988
|
[13]
|
88/F
|
PCP
|
N/A
|
N/A
|
1.2
|
1600
|
p.o.
|
4
|
33
|
N/A
|
|
Case 7
|
1988
|
[14]
|
64/M
|
PCP
|
ESRD on HD
|
60 mg/day p.o.
|
10
|
7680
|
i.v.
|
2
|
33
|
N/A
|
|
Case 8
|
1988
|
[15]
|
34/M
|
PCP
|
AIDS, Hepatitis B
|
N/A
|
N/A
|
N/A
|
N/A
|
6
|
22
|
12
|
|
Case 9
|
1992
|
[16]
|
19/F
|
N/A
|
ESRD on PD
|
N/A
|
N/A
|
1600
|
p.o.
|
1
|
17
|
N/A
|
|
Case 10
|
1992
|
[8]
|
72/M
|
Prophylaxis
|
Lymphoma
|
N/A
|
0.7
|
N/A
|
N/A
|
N/A
|
14
|
N/A
|
|
Case 11
|
1993
|
[17]
|
36/M
|
PCP
|
Renal transplant
|
N/A
|
2.7
|
4800/9600
|
i.v./ p.o.
|
62
|
33
|
N/A
|
|
Case 12
|
1997
|
[18]
|
73/M
|
Pneumonia
|
ARF
|
N/A
|
5.1
|
6000/3000
|
i.v./i.v.
|
69
|
22
|
N/A
|
|
Case 13
|
2000
|
[19]
|
91/F
|
UTI
|
N/A
|
N/A
|
1.7
|
3200
|
p.o.
|
7
|
34
|
N/A
|
|
Case 14
|
2001
|
[20]
|
41/M
|
PCP
|
AIDS, Hepatitis C
|
N/A
|
1.36
|
6400
|
p.o.
|
10
|
18
|
30.2
|
|
Case 15
|
2006
|
[6]
|
46/M
|
PCP
|
AIDS
|
N/A
|
1.97
|
6400
|
p.o.
|
18
|
29
|
20.6
|
|
Case 16
|
2008
|
[21]
|
76/M
|
Endophthalmitis
|
N/A
|
N/A
|
2.1
|
75 mg/kg/day
|
N/A
|
11
|
20
|
N/A
|
|
Case 17
|
2010
|
[4]
|
44/F
|
PCP
|
AIDS
|
80 mg/day i.v.
|
0.8
|
6400
|
i.v.
|
7
|
59
|
84
|
|
Case 18
|
2010
|
[4]
|
24/M
|
PCP
|
AIDS
|
80 mg/day i.v.
|
0.8
|
4800
|
i.v.
|
20
|
40
|
80
|
|
Case 19
|
2012
|
[22]
|
56/F
|
PCP
|
ESRD, Renal transplant
|
5 mg/day p.o.
|
N/A
|
N/A
|
N/A
|
5
|
31
|
N/A
|
|
Case 20
|
2012
|
[23]
|
83/M
|
Prophylaxis
|
Lymphoma
|
N/A
|
1.72
|
1600 (2 times a week)
|
p.o.
|
N/A
|
25
|
N/A
|
|
Case 21
|
2013
|
[24]
|
52/F
|
Prophylaxis
|
EGPA
|
40 mg/day p.o.
|
N/A
|
400
|
p.o.
|
N/A
|
31
|
42.6
|
|
Case 22
|
2017
|
[25]
|
69/M
|
Pneumonia
|
MPA, AKI, FN
|
Yes (N/A)
|
2.62
|
4800
|
N/A
|
4
|
28.8
|
99.4
|
|
Case 23
|
2017
|
The present case
|
54/F
|
PCP
|
RA, ESRD on PD
|
3 mg/day p.o.
|
8.96
|
1600
|
p.o.
|
10
|
15
|
69.4
|
-
F female, M male, TMP/SMX trimethoprim/sulfamethoxazole, UTI urinary tract infection, PCP Pneumocystis jirovecii pneumonia, N/A not available, CRF chronic renal failure, CHF congestive heart failure, ESRD end-stage renal disease, HD hemodialysis, DM diabetes mellitus, PD Parkinson’s disease, MM multiple myeloma, AIDS acquired immune deficiency syndrome, PD peritoneal dialysis, ARF acute renal failure, EGPA eosinophilic granulomatosis with polyangiitis, MPA microscopic polyangiitis, AKI acute kidney injury, FN febrile neutropenia, RA rheumatoid arthritis, p.o. per os, i.v. intravenous
