| |
Total (N = 50)
|
T1 (mean rCUC < 11.7 L/week/1.73m2), n = 17
|
T2 (mean rCUC 11.8–29.8 L/week/1.73m2), n = 17
|
T3 (mean rCUC ≥ 29.9 L/week/1.73m2), n = 16
|
P for trend
|
|---|
|
Total protein, g/dL
|
6.4 ± 0.7
|
6.5 ± 0.6
|
6.2 ± 0.6
|
6.4 ± 0.7
|
0.539
|
|
Albumin, g/dL
|
3.5 ± 0.4
|
3.5 ± 0.4
|
3.4 ± 0.5
|
3.6 ± 0.4
|
0.270
|
|
Blood urea nitrogen, mg/dL
|
65 ± 13
|
63 ± 10
|
68 ± 17
|
67 ± 12
|
0.460
|
|
Creatinine, mg/dL
|
11.5 ± 3.0
|
13.1 ± 3.1
|
11.1 ± 2.3
|
10.1 ± 3.0
|
0.003
|
|
Uric acid, mg/dL
|
6.8 ± 1.1
|
6.7 ± 1.2
|
6.7 ± 1.0
|
6.9 ± 1.1
|
0.341
|
|
Sodium, mEq/L
|
136 ± 4
|
134 ± 3
|
137 ± 3
|
139 ± 2
|
< 0.001
|
|
Potassium, mEq/L
|
4.4 ± 0.6
|
4.4 ± 0.7
|
4.2 ± 0.6
|
4.7 ± 0.5
|
0.306
|
|
Chloride, mEq/L
|
98 ± 5
|
94 ± 3
|
98 ± 4
|
102 ± 4
|
< 0.001
|
|
Calcium, mg/dL
|
9.5 ± 0.4
|
9.5 ± 0.4
|
9.5 ± 0.5
|
9.5 ± 0.4
|
0.643
|
|
Phosphate, mg/dL
|
5.4 ± 1.2
|
5.4 ± 1.7
|
5.3 ± 0.7
|
5.4 ± 1.2
|
0.894
|
|
Glucose, mg/dL
|
108 ± 31
|
112 ± 35
|
105 ± 26
|
107 ± 34
|
0.408
|
|
Total cholesterol, mg/dL
|
182 ± 44
|
168 ± 33
|
195 ± 58
|
183 ± 37
|
0.355
|
|
Triglyceride, mg/dL
|
126 ± 73
|
126 ± 84
|
114 ± 53
|
138 ± 82
|
0.569
|
|
LDL-C, mg/dL
|
96 ± 27
|
85 ± 22
|
105 ± 26
|
100 ± 30
|
0.176
|
|
HDL-C, mg/dL
|
52 ± 18
|
53 ± 14
|
53 ± 22
|
52 ± 16
|
0.794
|
|
Hb, g/dL
|
10.2 ± 1.1
|
9.8 ± 1.0
|
10.0 ± 1.2
|
10.9 ± 0.7
|
< 0.001
|
|
C-reactive protein, mg/dL
|
0.08 (0.03–0.13)
|
0.07 (0.04–0.15)
|
0.08 (0.03–0.22)
|
0.06 (0.03–0.11)
|
0.631
|
|
Serum iron, μg/dL
|
87 ± 26
|
84 ± 26
|
87 ± 31
|
88 ± 22
|
0.735
|
|
TIBC, μg/dL
|
283 ± 34
|
301 ± 34
|
268 ± 37
|
281 ± 22
|
0.074
|
|
TSAT, %
|
30.7 ± 9.3
|
28.2 ± 8.8
|
32.2 ± 10.3
|
31.7 ± 8.7
|
0.213
|
|
Ferritin, ng/mL
|
130 (80–220)
|
108 (73–205)
|
216 (89–306)
|
113 (59–177)
|
0.643
|
|
Whole PTH, pg/mL
|
94 (55–151)
|
89 (55–128)
|
92 (37–173)
|
97 (52–163)
|
0.801
|
|
BNP, pg/mL
|
86 (37–298)
|
222 (67–468)
|
101 (34–433)
|
47 (20–116)
|
0.023
|
|
eEPO, U/mL
|
16.0 (13.6–25.1)
|
22.1 (13.9–24.9)
|
17.7 (13.9–24.3)
|
18.6 (14.0–23.7)
|
0.618
|
|
BMG, mg/L
|
23.2 (18.1–28.8)
|
28.6 (26.6–37.3)
|
22.8 (19.9–29.6)
|
17.6 (14.6–18.9)
|
< 0.001
|
|
HbA1c, %
|
5.4 ± 0.7
|
5.3 ± 0.8
|
5.5 ± 0.7
|
5.5 ± 0.8
|
0.128
|
- Values are expressed as mean ± standard deviation or median (interquartile range) as appropriate
- Abbreviations:BMG β
2-microglobulin, BNP brain natriuretic peptide, eEPO endogenous erythropoietin, Hb hemoglobin, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, PTH parathyroid hormone, rCUC renal creatinine and urea clearance, TIBC total iron binding capacity, TSAT transferrin saturation
