Skip to main content

Table 3 Univariable and multivariable regression analysis for Hb levels

From: Positive association of residual kidney function with hemoglobin level in patients on peritoneal dialysis independent of endogenous erythropoietin concentration

  Univariable Multivariable
β-coefficient P β-coefficient Standardized β P
Male sex − 0.223 0.534    
Age, years 0.005 0.658    
Primary disease of kidney disease, DN − 0.383 0.254    
Dialysis duration, months 0.038 0.004 0.033 0.346 0.008
Body mass index, kg/m2 − 0.020 0.713    
Systolic blood pressure, mmHg − 0.014 0.199    
Diastolic blood pressure, mmHg 0.007 0.605    
Daily alcohol consumption 0.405 0.204    
Current smoker 0.927 0.020 0.240 0.170 0.211
Past histories of CVD 0.553 0.194    
History of peritonitis − 0.134 0.756    
CTR, % − 0.032 0.277 0.037 0.181 0.280
Dose of ESA, μg/week − 0.002 0.823 0.001 0.010 0.943
Dialysis modality, APD − 0.078 0.805    
Use of icodextrin 0.319 0.435    
Use of HG dialysate 0.258 0.437    
Total Kt/V, /week 1.038 0.021 0.330 0.104 0.425
Renal Kt/V, /week 1.400 < 0.001    
Peritoneal Kt/V, /week − 0.501 0.232    
Renal Ccr, L/week, /week/1.73m2 0.017 0.003    
Mean rCUC, L/week 0.024 0.002 0.018 0.321 0.045
Urine volume, L/day 0.630 0.009    
D/Pcr − 0.881 0.371    
Total protein, g/dL 0.322 0.183    
Albumin, g/dL 0.517 0.150    
Blood urea nitrogen, mg/dL − 0.020 0.103    
Creatinine, mg/dL − 0.092 0.077    
Uric acid, mg/dL 0.123 0.393    
Sodium, mEq/L 0.048 0.272    
Potassium, mEq/L 0.082 0.752    
Chloride, mEq/L 0.055 0.109    
Calcium, mg/dL 0.098 0.802    
Phosphate, mg/dL − 0.136 0.291    
Glucose, mg/dL 0.001 0.835    
Total cholesterol, mg/dL − 0.0001 0.969    
Triglyceride, mg/dL 0.003 0.209    
LDL-C, mg/dL 0.005 0.390    
HDL-C, mg/dL − 0.010 0.283    
Ln C-reactive protein, mg/dL − 0.123 0.329    
Serum iron, μg/dL − 0.004 0.539    
TIBC, μg/dL − 0.005 0.252    
TSAT, % − 0.004 0.813    
Ln ferritin, ng/dL − 0.569 0.009 − 0.276 − 0.177 0.221
Ln whole PTH, pg/mL − 0.018 0.924    
Ln BNP, pg/mL − 0.216 0.021 − 0.146 − 0.220 0.233
Ln eEPO, U/mL − 0.042 0.897 − 0.046 − 0.021 0.884
Ln BMG, mg/L − 0.545 0.200    
HbA1c, % 0.098 0.649    
Use of RAS inhibitors 1.248 0.116    
Use of calcium channel blockers − 0.431 0.227    
Use of β blockers − 0.153 0.629    
Use of calcium-containing PBs − 0.135 0.780    
Use of non-calcium-containing PBs − 0.145 0.650    
Use of iron preparations 0.044 0.908    
Use of vitamin D − 0.108 0.733    
Use of cinacalcet hydrochloride 0.175 0.764    
  1. Variables with a P value of < 0.05 in the univariable analysis were included in addition to CTR, ESA dose, and log-transformed eEPO in the multivariable analyses. Renal Kt/V, renal Ccr, and urine volume were excluded from multivariable analysis because of their multicollinearity with mean rCUC. The values written in Italic letter show significant association with Hb levels. A P value of < 0.05 was considered statistically significant
  2. Abbreviations: APD automated peritoneal dialysis, BMG β 2-microglobulin, BNP brain natriuretic peptide, CTR cardiothoracic ratio, Ccr creatinine clearance, DN diabetic nephropathy, D/Pcr dialysate-to-plasma creatinine ratio, eEPO endogenous erythropoietin, ESA erythropoiesis-stimulating agent, Hb hemoglobin, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, HG high-glucose (2.5%), Kt/V urea clearance, LDL-C low-density lipoprotein cholesterol, Ln log-transformed, PBs phosphate binders, PTH parathyroid hormone, RAS renin-angiotensin system, rCUC renal creatinine and urea clearance, TIBC total iron binding capacity, TSAT transferrin saturation