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Table 3 Univariable and multivariable regression analysis for Hb levels

From: Positive association of residual kidney function with hemoglobin level in patients on peritoneal dialysis independent of endogenous erythropoietin concentration

 

Univariable

Multivariable

β-coefficient

P

β-coefficient

Standardized β

P

Male sex

− 0.223

0.534

   

Age, years

0.005

0.658

   

Primary disease of kidney disease, DN

− 0.383

0.254

   

Dialysis duration, months

0.038

0.004

0.033

0.346

0.008

Body mass index, kg/m2

− 0.020

0.713

   

Systolic blood pressure, mmHg

− 0.014

0.199

   

Diastolic blood pressure, mmHg

0.007

0.605

   

Daily alcohol consumption

0.405

0.204

   

Current smoker

0.927

0.020

0.240

0.170

0.211

Past histories of CVD

0.553

0.194

   

History of peritonitis

− 0.134

0.756

   

CTR, %

− 0.032

0.277

0.037

0.181

0.280

Dose of ESA, μg/week

− 0.002

0.823

0.001

0.010

0.943

Dialysis modality, APD

− 0.078

0.805

   

Use of icodextrin

0.319

0.435

   

Use of HG dialysate

0.258

0.437

   

Total Kt/V, /week

1.038

0.021

0.330

0.104

0.425

Renal Kt/V, /week

1.400

< 0.001

   

Peritoneal Kt/V, /week

− 0.501

0.232

   

Renal Ccr, L/week, /week/1.73m2

0.017

0.003

   

Mean rCUC, L/week

0.024

0.002

0.018

0.321

0.045

Urine volume, L/day

0.630

0.009

   

D/Pcr

− 0.881

0.371

   

Total protein, g/dL

0.322

0.183

   

Albumin, g/dL

0.517

0.150

   

Blood urea nitrogen, mg/dL

− 0.020

0.103

   

Creatinine, mg/dL

− 0.092

0.077

   

Uric acid, mg/dL

0.123

0.393

   

Sodium, mEq/L

0.048

0.272

   

Potassium, mEq/L

0.082

0.752

   

Chloride, mEq/L

0.055

0.109

   

Calcium, mg/dL

0.098

0.802

   

Phosphate, mg/dL

− 0.136

0.291

   

Glucose, mg/dL

0.001

0.835

   

Total cholesterol, mg/dL

− 0.0001

0.969

   

Triglyceride, mg/dL

0.003

0.209

   

LDL-C, mg/dL

0.005

0.390

   

HDL-C, mg/dL

− 0.010

0.283

   

Ln C-reactive protein, mg/dL

− 0.123

0.329

   

Serum iron, μg/dL

− 0.004

0.539

   

TIBC, μg/dL

− 0.005

0.252

   

TSAT, %

− 0.004

0.813

   

Ln ferritin, ng/dL

− 0.569

0.009

− 0.276

− 0.177

0.221

Ln whole PTH, pg/mL

− 0.018

0.924

   

Ln BNP, pg/mL

− 0.216

0.021

− 0.146

− 0.220

0.233

Ln eEPO, U/mL

− 0.042

0.897

− 0.046

− 0.021

0.884

Ln BMG, mg/L

− 0.545

0.200

   

HbA1c, %

0.098

0.649

   

Use of RAS inhibitors

1.248

0.116

   

Use of calcium channel blockers

− 0.431

0.227

   

Use of β blockers

− 0.153

0.629

   

Use of calcium-containing PBs

− 0.135

0.780

   

Use of non-calcium-containing PBs

− 0.145

0.650

   

Use of iron preparations

0.044

0.908

   

Use of vitamin D

− 0.108

0.733

   

Use of cinacalcet hydrochloride

0.175

0.764

   
  1. Variables with a P value of < 0.05 in the univariable analysis were included in addition to CTR, ESA dose, and log-transformed eEPO in the multivariable analyses. Renal Kt/V, renal Ccr, and urine volume were excluded from multivariable analysis because of their multicollinearity with mean rCUC. The values written in Italic letter show significant association with Hb levels. A P value of < 0.05 was considered statistically significant
  2. Abbreviations: APD automated peritoneal dialysis, BMG β 2-microglobulin, BNP brain natriuretic peptide, CTR cardiothoracic ratio, Ccr creatinine clearance, DN diabetic nephropathy, D/Pcr dialysate-to-plasma creatinine ratio, eEPO endogenous erythropoietin, ESA erythropoiesis-stimulating agent, Hb hemoglobin, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, HG high-glucose (2.5%), Kt/V urea clearance, LDL-C low-density lipoprotein cholesterol, Ln log-transformed, PBs phosphate binders, PTH parathyroid hormone, RAS renin-angiotensin system, rCUC renal creatinine and urea clearance, TIBC total iron binding capacity, TSAT transferrin saturation
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Renal Replacement Therapy

ISSN: 2059-1381

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