Table 1 Cases
From: Blood purification therapies in methotrexate-induced acute kidney injury: four case reports
|  | Primary disease | Dose of MTX (g) per day (per body surface area) | eGFR prior to administration [mL/min/1.73 m2], serum Cre [mg/dL] | MTX maximum blood concentration [μmol/L] |
|---|---|---|---|---|
Case 1, age 36Â years, male | Diffuse large B cell lymphoma, central nervous system reoccurrence | 5.8Â g/day (3.5Â g/m2) | eGFR 88.5, Cre 0.8 | MTX blood concentration 31.0 |
Case 2, age 45Â years, male | Acute lymphatic leukemia | 4.6Â g/day (3.0Â g/m2) | eGFR 96.1, Cre 0.7 | MTX blood concentration 23.0 |
Case 3, age 16Â years, male | Acute lymphatic leukemia | 9.8Â g/day (5.0Â g/m2) | eGFR 178.8, Cre 0.49 | MTX blood concentration 138.8 |
Case 4, age 75Â years, female | Osteosarcoma, metastasis to both lungs | 13.6Â g/day (8.6Â g/m2) | eGFR 81.5, Cre 0.54 | MTX blood concentration 442.0 |