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Table 1 Cases

From: Blood purification therapies in methotrexate-induced acute kidney injury: four case reports

  Primary disease Dose of MTX (g) per day (per body surface area) eGFR prior to administration [mL/min/1.73 m2], serum Cre [mg/dL] MTX maximum blood concentration [μmol/L]
Case 1, age 36 years, male Diffuse large B cell lymphoma, central nervous system reoccurrence 5.8 g/day (3.5 g/m2) eGFR 88.5, Cre 0.8 MTX blood concentration 31.0
Case 2, age 45 years, male Acute lymphatic leukemia 4.6 g/day (3.0 g/m2) eGFR 96.1, Cre 0.7 MTX blood concentration 23.0
Case 3, age 16 years, male Acute lymphatic leukemia 9.8 g/day (5.0 g/m2) eGFR 178.8, Cre 0.49 MTX blood concentration 138.8
Case 4, age 75 years, female Osteosarcoma, metastasis to both lungs 13.6 g/day (8.6 g/m2) eGFR 81.5, Cre 0.54 MTX blood concentration 442.0
  1. MTX methotrexate, eGFR estimated glomerular filtration rate, Cre creatinine