| |
Stenosis grade
|
|---|
|
Baseline Characteristics
|
All
|
Low
|
Intermediate
|
High
| |
|---|
| |
75≤, < 90%
|
90≤, < 95%
|
95%≤
|
p value
|
|---|
|
N = 74
|
N = 24(33%)
|
N = 38(51%)
|
N = 12(16%)
| |
|---|
|
Stenosis rate (%)
|
87 ± 8.7
| | | | |
|
Age (year)
|
72 ± 7
|
72 ± 5
|
72 ± 7
|
72 ± 8
|
0.95
|
|
Male (%)
|
70
|
75
|
68
|
83
|
0.59
|
|
Smoking (%)
|
75
|
65
|
54
|
67
|
0.73
|
|
Comorbidities (%)
|
|
DM
|
34
|
29
|
32
|
50
|
0.43
|
|
Hypertension
|
100
|
100
|
100
|
100
|
–
|
|
Hyperlipidemia
|
61
|
63
|
56
|
75
|
0.48
|
|
IHD
|
92
|
92
|
97*
|
75**
|
0.047†
|
|
CVD
|
19
|
17
|
16
|
33
|
0.38
|
|
PAD
|
36
|
42
|
34
|
33
|
0.82
|
|
Blood pressure
|
|
Systolic (mmHg)
|
147 ± 22
|
145 ± 21
|
145 ± 20
|
160 ± 27
|
0.10
|
|
Diastolic (mmHg)
|
79 ± 12
|
79 ± 14
|
79 ± 9
|
84 ± 17
|
0.45
|
|
Laboratory data
|
|
BUN (mg/dl)
|
22.5 ± 11.7
|
19.2 ± 7.9
|
21.6 ± 11.8
|
31.0 ± 16.7
|
0.07
|
|
Creatinine (mg/dl)
|
1.27 ± 0.68
|
1.20 ± 0.59*
|
1.10 ± 0.35*
|
1.95 ± 1.14**
|
0.0004†
|
|
eGFR (mL/min/1.73 m2)
|
47.9 ± 16.1
|
49.3 ± 15.0
|
51.1 ± 14.5
|
35.2 ± 18.2
|
0.0087†
|
|
Albumin (g/dl)
|
4.0 ± 0.4
|
4.0 ± 0.4
|
4.1 ± 0.4
|
3.8 ± 0.7
|
0.43
|
|
LDL-Cho (mg/dl)
|
99 ± 27
|
90 ± 25*
|
98 ± 23
|
118 ± 36**
|
0.017†
|
|
U-TP (g/gcr)
|
1.5 ± 0.3
|
0.29 ± 0.74*
|
0.22 ± 0.62*
|
1.21 ± 1.44**
|
0.002†
|
|
Stenosis findings
|
|
Lateral RAS (%)
|
76
|
87*
|
76
|
50**
|
0.047†
|
|
Bilateral RAS (%)
|
24
|
13*
|
24
|
50**
|
|
Renal size (cm)
|
9.4 ± 0.9
|
9.5 ± 0.8
|
9.2 ± 1.0
|
8.8 ± 0.7
|
0.10
|
|
PSV (cm/s)
|
254 ± 99
|
233 ± 54*
|
280 ± 106*
|
199 ± 120**
|
0.032†
|
|
EDV (cm/s)
|
65 ± 9
|
57 ± 11*
|
77 ± 15*
|
40 ± 22**
|
0.011†
|
|
Resistive index
|
0.75 ± 0.10
|
0.75 ± 0.09
|
0.73 ± 0.08
|
0.79 ± 0.08
|
0.14
|
|
Medical therapy (%)
|
|
ARB
|
45
|
42
|
47
|
33
|
0.58
|
|
ACEi
|
27
|
42
|
16
|
33
|
0.10
|
|
Ca blocker
|
65
|
58
|
63
|
83
|
0.48
|
|
β or α/β blocker
|
38
|
46
|
32
|
42
|
0.76
|
|
Statin
|
58
|
50
|
61
|
67
|
0.13
|
|
Observational period
|
|
Median (IQR), months
|
83(49,106)
|
89(51,114)
|
76(48,105)
|
80(56,95)
|
0.69
|
- Data were expressed as mean ± SD or %
- Expanded abbreviation; RAS renal artery stenosis, DM diabetes meliitus, IHD ischemic heart disease, CVD cerebral vascular disease, PAD peripheral arterial disease, eGFR estimated glomerular filtration rate, U-TP urine total protein, PSV peak systolic velocity, EDV end-diastolic velocity, ARB angiotensin type II receptor blocker, ACEi angiotensin converting enzyme inhibitor
- †P value was less than 0.05 by one-way analysis of variance
- P value between ** and * was less than 0.05 with post-hoc the Bonferroni test
