Table 4 Iron status and FGF23

 Bozentowics- Wikarek M et al.

3780 elderly

Low iron levels are associated with increased FGF23 levels. FGF23 levels were nearly linearly increased by 0.285 pg/mL for each unit of serum iron decrease in patients with serum iron levels < 59 ng/mL,

[144]

 Lewerin C et al.

1010 elderly

FGF 47.4 μmol/L (transferrin saturation (TS) < 15%) vs 41.9 μmol/L (TS > 15%)

[145]

 Braithwaite V. et al.

79 children non-CKD

Iron status is a negative predictor of plasma FGF23 concentration. Improvements in iron status following iron supplementation are associated with a significant decrease in FGF23 concentration.

[146]

 Deger SM et al.

73 hemodialysis

There was a negative relationship between iron administration and serum iFGF23 level in a dialysis population

[150]

 Yamashita K et al.

31 hemodialysis

Serum FGF23 was reduced from 1820 pg/mL (342-4370) to 1240 pg/mL (214-2840) after 3-month treatment with sodium ferrous citrate.

[151]

 Takeda Y, et al

27 hemodialysis

Intravenous saccharated ferric oxide induces further increase in FGF23 levels.

[152]

 Iguchi A et al

124 hemodialysis

Serum FGF23 level decreased from 2000 pg/mL (1300-3471.4) to 1771.4 pg/mL (1142.9-2342.9) after switching from sevelamer to ferric citrate hydrate.

[154]

 David V et al

Mice

Three-week low iron diet intake resulted in significantly increased levels of bone FGF23 mRNA. Functional iron deficiency with hepcidin injection caused increased bone expression of FGF23 mRNA.

[147]

 Hanudel MR et al

Adenin-induced CKD mice

Eight-week adenine-containing and low iron diet intake increased the bone FGF23 mRNA levels.

[148]

 Farrow EG et al.

Mice

Mice receiving low-iron diet had significantly elevated bone Fgf23 mRNA.

[149]

 Gravesen E et al.

Non-iron depleted uremic rats

Intravenous iron isomaltoside and ferric carboxymaltose had no effect on plasma levels of FGF23 and phosphate.

[153]