Skip to main content

Table 5 ORs of dementia with covariates

From: Is hemodialysis itself a risk factor for dementia? An analysis of nationwide registry data of patients on maintenance hemodialysis in Japan

Covariates Number of patients Incident number* OR for development of dementia   ( 95% CI )   p value Covariates Number of patients Incident number* OR for development of dementia   ( 95% CI )   p value
Age            History of myocardial infarction          
  For every 10 years old 120,101 4031 1.05 ( 1.02 1.07 ) 0.0003   No 113,283 3762 1.00   Reference   
Sex             Yes 6610 265 1.02 ( 0.91 1.14 ) 0.7
  Male 74,472 2112 1.00   Reference     No information available 208 4 0.61 ( 0.30 1.25 ) 0.2
  Female 45,629 1919 1.14 ( 1.08 1.21 ) 0.0001 History of limb amputation          
Comorbidity of diabetes            No 117,449 3911 1.00   Reference   
  Without diabetes 80,207 2439 1.00   Reference     Yes 2455 111 0.66 ( 0.56 0.77 ) 0.0001
  With diabetes 39,894 1592 1.00 ( 0.94 1.07 ) 0.9   No information available 197 9 1.03 ( 0.53 2.00 ) 0.9
Kt/V            History of hip fracture          
  For every 0.1 increase 112,533 3690 1.00 ( 0.99 1.01 ) 0.5   No 117,467 3789 1.00   Reference   
  No information available 7568 341 1.00 ( 0.83 1.19 ) 1.0   Yes 2121 219 2.38 ( 2.10 2.71 ) 0.0001
Body mass index            No information available 513 23 1.26 ( 0.82 1.93 ) 0.3
  For every 1 kg/m2 increase 105,234 3390 0.99 ( 0.98 1.00 ) 0.2 Activities of daily living          
  No information available 14,867 641 1.01 ( 0.81 1.25 ) 1.0   No symptoms 66,253 1009 1.00   Reference   
Serum albumin level            Moderate symptoms 37,309 1159 1.13 ( 1.05 1.22 ) 0.001
  For every 1.0 g/dl increase 116,318 3923 0.96 ( 0.89 1.04 ) 0.3   ≥ 50% sitting up§ 10,184 1050 4.49 ( 4.14 4.88 ) 0.0001
  No information available 3783 108 0.76 ( 0.55 1.06 ) 0.1   ≥ 50% in bed# 3680 548 9.60 ( 8.69 10.6 ) 0.0001
CRP level            Whole day in bed 1132 224 21.70 ( 18.7 25.2 ) 0.0001
  For every 1.0 mg/dl increase 58,498 2276 1.02 ( 1.00 1.04 ) 0.03   No information available 1543 41 0.95 ( 0.66 1.37 ) 0.8
  No information available 61,603 1755 0.94 ( 0.88 1.02 ) 0.1 Place of residence          
Hemoglobin level            Homes 114,690 3286 1.00   Reference   
  For every 1.0 g/dl increase 118,829 3967 0.99 ( 0.97 1.01 ) 0.5   Care facilities^ 1109 191 10.95 ( 9.53 12.6 ) 0.0001
  No information available 1272 64 1.18 ( 0.84 1.65 ) 0.3   Hospitals 3393 526 5.32 ( 4.86 5.84 ) 0.0001
             No information available 909 28 1.15 ( 0.73 1.82 ) 0.5
  1. The associations between the covariates and dementia risk, which were obtained from the whole patient group analysis using a multifactor model, are shown
  2. ADLs activities of daily living, CI confidence interval, CRP C-reactive protein, OR odds ratio
  3. *Number of patients with dementia
  4. No symptoms (the patient can perform social activities without symptoms and behave without restrictions)
  5. Moderate symptoms (the patient has mild symptoms and has trouble with physical work, but can walk and do light and sedentary work, such as light domestic and clerical work)
  6. §≥ 50% sitting up (the patient can walk and take care of him/herself, but sometimes requires care. The patient can sit up at least half of the day, but cannot do light work)
  7. #≥ 50% in bed (the patient can take care of him/herself to some extent, but often requires care and is in bed at least half of the day)
  8. Whole day in bed (the patient cannot take care of him/herself and requires constant care. The patient must be in bed all day)
  9. Patients’ own home
  10. ^Care facilities (e.g., homes with care services; nursing homes, such as private nursing homes without national aid and nursing homes for families with financial difficulties; group homes; vocational centers; or relief facilities)
  11. Hospitals (e.g., health service facilities for the elderly; beds for general patients, patients at chronic stage, patients requiring rehabilitation, and patients with mental illness and infectious diseases, such as tuberculosis)