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Table 4 Result items that were evaluated for 12 months in patients who completed the study and were not withdrawn

From: The clinical evaluation of novel polymethyl methacrylate membrane with a modified membrane surface: a multicenter pilot study

Items Baseline 3 months 6 months 9 months 12 months
NF group PS group NF group PS group NF group PS group NF group PS group NF group PS group
Number of patients 14 17 14 17 14 17 14 17 14 17
CRP (mg/dL) 0.55 ± 0.52 0.75 ± 0.66 0.53 ± 0.60 0.99 ± 2.03 0.61 ± 0.65 0.71 ± 0.83 0.68 ± 0.88 0.62 ± 0.46 0.64 ± 0.94 0.49 ± 0.42
nPCR (g/kg/day) 0.88 ± 0.17 0.90 ± 0.15 0.89 ± 0.16 0.85 ± 0.134 0.89 ± 0.14 0.89 ± 0.16 0.91 ± 0.16 0.91 ± 0.16 0.86 ± 0.12 0.86 ± 0.17
%CGR (%) 114 ± 25 115 ± 18 117 ± 23 109 ± 21 112 ± 21 107 ± 21# 117 ± 18 108 ± 18# 119 ± 20 109 ± 24
Albumin (g/dL) 3.6 ± 0.3 3.5 ± 0.3 3.4 ± 0.4# 3.5 ± 0.3 3.4 ± 0.3# 3.6 ± 0.3 3.5 ± 0.3 3.5 ± 0.3 3.5 ± 0.3 3.5 ± 0.3
MNA-SF 13 ± 1 13 ± 1 12 ± 2 13 ± 1 13 ± 1 13 ± 2 13 ± 1 13 ± 1 12 ± 2 13 ± 1
MNA screening score (n)
 Normal nutritional status 14 16 11 16 13 15 13 14 12 13
 At risk of malnutrition 0 1 3 1 1 2 1 3 2 4
 Malnourished 0 0 0 0 0 0 0 0 0 0
Itchiness (VAS values) 22.1 ± 19.8 14.1 ± 16.6 21.6 ± 17.4 20.6 ± 19.5 27.9 ± 28.9 30.5 ± 25.6 12.1 ± 20.4$ 24.7 ± 21.0 14.1 ± 23.8 19.1 ± 19.0
Body weight (kg) 61.4 ± 12.0 66.3 ± 13.4 61.5 ± 11.8 66.0 ± 12.7 61.2 ± 11.5 65.7 ± 12.3 61.0 ± 11.4 65.2 ± 12.2 60.5 ± 11.1 64.9 ± 11.9
Reduction rate of weight (%) – – 0.1 ± 1.7 − 0.2 ± 1.5 − 0.3 ± 1.8 − 0.6 ± 2.1 − 0.6 ± 1.9 − 1.4 ± 3.0 − 1.3 ± 1.8 − 1.6 ± 4.1
 Mild – – 3 6 7 6 8 6 9 5
 Moderate – – 0 0 0 1 0 3 0 4
 Severe – – 0 0 0 0 0 0 0 0
Blood cell counts
 White blood cell (/μL) 6676 ± 2115 7207 ± 1972 6536 ± 1934 6952 ± 1827 7093 ± 2164 7170 ± 2155 6783 ± 2442 7010 ± 1729 7087 ± 2278 6836 ± 2528
 Red blood cell (× 104/μL) 359 ± 29 356 ± 42 360 ± 21 355 ± 39 360 ± 37 358 ± 46 371 ± 42 353 ± 39 354 ± 42 353 ± 47
 Platelet (× 104/μL) 21.6 ± 6.7 20.7 ± 4.9 20.7 ± 5.7 19.5 ± 4.9 22.4 ± 7.3 18.9 ± 4.2# 22.3 ± 7.6 18.7 ± 4.3# 22.1 ± 6.2 19.5 ± 4.3
Dialysis dose
 Kt/V 1.50 ± 0.26 1.56 ± 0.23 1.51 ± 0.25 1.56 ± 0.22 1.52 ± 0.27 1.54 ± 0.22 1.51 ± 0.25 1.54 ± 0.21 1.51 ± 0.26 1.57 ± 0.24
  1. MNA screening score: normal nutritional status, 12–14 points; at risk of malnutrition, 8–11 points; malnourished, 0–7 points
  2. Reduction rate of weight (%): mild, 0–5%; moderate, 5–10%, severe, ≥ 10%
  3. CRP C-reactive protein, %CGR % creatinine generation rate, nPCR normalized protein catabolic rate, MNA-SF Mini nutrition Assessment-short form, VAS visual analog scale, NF Filtryzer® NF, PS polysulfone
  4. #p < 0.05 vs. baseline; $p < 0.05 vs. PS group
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Renal Replacement Therapy

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