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Table 3 Representative randomized controlled trials for IDPN

From: A case of refeeding syndrome during intradialytic parenteral nutrition

  FineS trial 2007 German IDPN trial 2017
Inclusion criteria
 Age 18–80 years old > 18 years old
 Hemodialysis vintage > 6 months > 6 months
 BMI < 20 kg/m2  
 BW loss within 6 months > 10%  
 Serum albumin < 3.5 g/dL < 3.5 g/dL
 Serum prealbumin < 30 mg/dL < 25 mg/dL
 SGA   B or C
Exposure IDPN with oral nutritional supplements for 1 year IDPN (3 times per week) with standardized nutritional counseling over 16 weeks
Comparison Oral nutritional supplements only Standardized nutritional counseling only
Outcome IDPN did not have additional benefit on 2-year all-cause mortality IDPN significantly increased prealbumin (changes in serum prealbumin from baseline to week 16) (p = 0.02)
  1. BMI body mass index, BW body weight, IBW ideal body weight, SGA subjective global assessment