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Table 4 Estimation of unknown baseline serum creatinine

From: The Japanese Clinical Practice Guideline for acute kidney injury 2016

Estimating baseline sCr method

Characteristics in the diagnosis of AKI

Reference

An estimated sCr determined by back-calculation using MDRD assuming a GFR of 75 mL/min/1.73 m2

Low specificity especially in CKD patients

[18,19,20,21,22,23,24]

An estimated sCr determined by back-calculation using MDRD assuming a GFR of 100 mL/min/1.73 m2

Very high sensitivity and very low specificity

[23]

The first admission sCr

Low sensitivity

[22]

A minimum inpatient sCr during the first 7 days

Low specificity

[22]

A minimum sCr during the first 7 days in the ICU

Low specificity although tendency to underestimate the AKI stage

[23]

An estimated sCr using multiple imputation methods such as sex, race, comorbidity (CKD, etc.), and a minimum inpatient sCr

High specificity

[19]

A minimum inpatient sCr

 

[11]

sCr = 1.0 mg/dL (male)/0.8 mg/dL (female)

 

[25]

  1. sCr serum creatinine, GFR glomerular filtration rate, CKD chronic kidney disease