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Table 9 Urinary NGAL for early AKI diagnosis

From: The Japanese Clinical Practice Guideline for acute kidney injury 2016

Reference

Author, year

Cohort

All case (n)

AKI case

AKI definition

Urine sampling

Cutoff

Sensitivity

Specificity

AUC (95% CI)

n

%

sCr criteria

UO criteria

     

[123]

Koyner et al. 2008

Cardiac surgery

72

34

47

Increase ≥ 25% in 3 days OR RRT

N/A

ICU admission

572 ng mgCr−1

0.61

0.73

0.71 (0.58–0.83)

[124]

Tuladhar et al. 2009

Cardiac surgery

50

9

18

Increase ≥ 0.5 mg/dL in 48 h

N/A

2 h postoperative

393 ng mmolCr−1

0.93

0.78

0.96 (0.90–1.00)

[138]

Paarmann et al. 2013

Cardiac surgery

136

29

21

AKIN ≥ 1

N/A

6 h postoperative

NR

NR

NR

0.61 (0.48–0.73)

[125]

de Geus et al. 2011

ICU

632

171

27

RIFLE≥ R

N/A

ICU admission

NR

NR

NR

0.80

[126]

Wagener et al. 2006

Cardiac surgery

81

16

20

RIFLE ≥ R

N/A

18 h postoperative

213 ng ml−1

0.73

0.78

0.80 (0.57–1.03)

[127]

Wagener et al. 2008

Cardiac surgery

426

85

20

AKIN ≥ 1

N/A

18 h postoperative

65 ng ml−1

0.39

0.78

0.61 (0.54–0.68)

[128]

Xin et al. 2008

Cardiac surgery

33

9

27

AKIN ≥ 1

AKIN ≥ 1

2 h postoperative

250 μg mmolCr−1

0.81

0.78

0.93

[129]

Han et al. 2009

Cardiac surgery

90

36

40

Increase ≥ 0.5 mg/dL in 72 h

N/A

3 h postoperative

456 ng mgCr−1

0.71

0.39

0.65 (0.54–0.76)

[130]

Liangos et al. 2009

Cardiac surgery

103

13

13

Increase ≥ 50% in 72 h

N/A

2 h post-CPB

166 ng mgCr−1

0.67

0.11

0.50 (0.33–0.68)

[131]

Makris et al. 2009

ICU

31

11

35

RIFLE ≥ R

N/A

ICU admission

25 ng ml−1

0.91

0.95

0.98 (0.82–0.98)

[132]

Heise et al. 2011

Cardiac surgery

50

38

76

AKIN ≥ 1

AKIN ≥ 1

6 h after ICU admission

16.8 μg L−1

0.82

0.78

0.77 (0.63–0.88)

[133]

Ejaz et al. 2012

Cardiac surgery

100

27

27

AKIN ≥ 1

N/A

24 h after operation

NR

NR

NR

0.62 (0.49–0.75)

[134]

Sargenti et al. 2012

Cardiac surgery

52

15

29

AKIN ≥ 1

AKIN ≥ 1

4 h postoperative

55.2 μg gCr−1

0.55

0.73

0.71 (0.56–0.85)

[135]

Liebetrau et al. 2013

Cardiac surgery

141

19

13

KDIGO ≥ 2

KDIGO ≥ 2

4 h postoperative

NR

NR

NR

0.90 (0.81–0.99)

[136]

Liu et al. 2013

Cardiac surgery

109

26

24

AKIN ≥ 1

N/A

2 h postoperative

33.73 ng mgCr−1

0.81

0.83

0.87 (0.78–0.97)

[137]

Munir et al. 2013

Cardiac surgery

88

11

13

AKIN ≥ 1

AKIN ≥ 1

4 h postoperative

87 ng ml−1

0.91

0.99

0.91 (0.83–0.96)

  1. sCr serum creatinine, UO urine output, RRT renal replacement therapy, AUC area under the curve, 95% CI 95% confidence interval, NR not reported