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Table 3 Differential diagnoses of hypereosinophilia [8]

From: Hypereosinophilic syndrome manifested as eosinophilic gastroenteritis and colitis in a patient undergoing hemodialysis

Category Examples
• Allergic disorders Asthma, atopic dermatitis
• Drug hypersensitivity Eosinophilia-myalgia syndrome, DRESS, interstitial nephritis, eosinophilic hepatitis
• Infection
 ▪ Helminthic Strongyloidiasis, trichinellosis, filariasis, schistosomiasis, hookworm
 ▪ Ectoparasitic Scabies, myiasis
 ▪ Protozoan Isosporiasis, sarcocystis myositis
 ▪ Fungal Coccidiodomycosis, allergic bronchopulmonary aspergillosis, histoplasmosis
 ▪ Viral HIV
• Neoplasia Leukemia, lymphoma, adenocarcinoma
• Immunologic disorders
 ▪ Immunodeficiency DOCK8 deficiency, hyper-IgE syndrome, Omenn’s syndrome
 ▪ Autoimmune and idiopathic Sarcoidosis, inflammatory bowel disease, IgG4 disease, other connective tissue diseases
• Miscellaneous Radiation exposure, cholesterol emboli, hypoadrenalism, IL-2 therapy
• Rare eosinophilic disorders Idiopathic HES, EGPA, EGIDs
  1. DRESS drug reaction with eosinophilia and systemic symptoms, HIV human immunodeficiency virus, DOCK8 dedicator of cytokinesis 8, IgE immunoglobulin E, IgG4 immunoglobulin G4, IL-2 interleukin-2, EGPA eosinophilic granulomatosis with polyangiitis, EGIDs eosinophilic gastrointestinal disorders