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Table 5 Relative risk of 28-day mortality using univariate and multivariate logistic regression models

From: Using Sepsis-3 criteria to predict prognosis of patients receiving continuous renal replacement therapy for community-acquired sepsis: a retrospective observational study

Variable 28-day mortality
Univariate analysis Multivariate analysis
Odds ratio (95% CI) P value Odds ratio (95% CI) P value
Age ≥ 65 years 2.80 (0.91–8.63) 0.1 2.61 (0.77–9.80) 0.12
Male sex 0.98 (0.31–3.11) 1   
Hypertension 1.70 (0.57–5.06) 0.42   
Diabetes 0.30 (0.06–1.47) 0.19   
Smoking 2.68 (0.89–8.04) 0.1   
Alcoholism 0.28 (0.03–2.43) 0.41   
Positive cultures 0.65 (0.22–1.93) 0.59   
Pre-hospital antimicrobial therapy 2.22 (0.75–6.65) 0.18 3.10 (0.92–11.7) 0.068
Operation before starting CRRT 0.79 (0.24–2.64) 0.77   
PMX-DHP combination 1.78 (0.58–5.41) 0.39   
AKI at the start of CRRT 0.55 (0.17–1.74) 0.37   
Lactate ≥ 2 mmol/L 6.80 (1.74–26.6) 0.003* 8.16 (2.12–42.8) 0.0015*
Mean blood pressure ≤ 65 mmHg 2.38 (0.80–7.09) 0.16   
Use of catecholamine 1.33 (0.37–4.85) 0.76   
SOFA score ≥ 14 6.33 (1.85–21.6) 0.0039*   
APACHE II score ≥ 36 3.18 (1.01–10.0) 0.07   
Septic shock (Sepsis-3) 6.80 (1.74–26.6) 0.003*   
Septic shock (Sepsis-1) 2.18 (0.72–6.57) 0.25   
  1. Values are expressed as median (interquartile range)
  2. The covariates in the multivariable-adjusted models were age ≥ 65 years, pre-hospital antimicrobial therapy, and lactate ≥ 2 mmol/L
  3. Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B-immobilized fiber column direct hemoperfusion, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation
  4. *P < 0.05