Using Sepsis-3 criteria to predict prognosis of patients receiving continuous renal replacement therapy for community-acquired sepsis: a retrospective observational study

Table 5 Relative risk of 28-day mortality using univariate and multivariate logistic regression models

Variable	28-day mortality
	Univariate analysis		Multivariate analysis
	Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
Age ≥ 65 years	2.80 (0.91–8.63)	0.1	2.61 (0.77–9.80)	0.12
Male sex	0.98 (0.31–3.11)	1
Hypertension	1.70 (0.57–5.06)	0.42
Diabetes	0.30 (0.06–1.47)	0.19
Smoking	2.68 (0.89–8.04)	0.1
Alcoholism	0.28 (0.03–2.43)	0.41
Positive cultures	0.65 (0.22–1.93)	0.59
Pre-hospital antimicrobial therapy	2.22 (0.75–6.65)	0.18	3.10 (0.92–11.7)	0.068
Operation before starting CRRT	0.79 (0.24–2.64)	0.77
PMX-DHP combination	1.78 (0.58–5.41)	0.39
AKI at the start of CRRT	0.55 (0.17–1.74)	0.37
Lactate ≥ 2 mmol/L	6.80 (1.74–26.6)	0.003*	8.16 (2.12–42.8)	0.0015*
Mean blood pressure ≤ 65 mmHg	2.38 (0.80–7.09)	0.16
Use of catecholamine	1.33 (0.37–4.85)	0.76
SOFA score ≥ 14	6.33 (1.85–21.6)	0.0039*
APACHE II score ≥ 36	3.18 (1.01–10.0)	0.07
Septic shock (Sepsis-3)	6.80 (1.74–26.6)	0.003*
Septic shock (Sepsis-1)	2.18 (0.72–6.57)	0.25

Values are expressed as median (interquartile range)
The covariates in the multivariable-adjusted models were age ≥ 65 years, pre-hospital antimicrobial therapy, and lactate ≥ 2 mmol/L
Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B-immobilized fiber column direct hemoperfusion, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation
*P < 0.05

ISSN: 2059-1381