|
Variable
|
28-day mortality
|
|---|
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
Odds ratio (95% CI)
|
P value
|
Odds ratio (95% CI)
|
P value
|
|---|
|
Age ≥ 65 years
|
2.80 (0.91–8.63)
|
0.1
|
2.61 (0.77–9.80)
|
0.12
|
|
Male sex
|
0.98 (0.31–3.11)
|
1
| | |
|
Hypertension
|
1.70 (0.57–5.06)
|
0.42
| | |
|
Diabetes
|
0.30 (0.06–1.47)
|
0.19
| | |
|
Smoking
|
2.68 (0.89–8.04)
|
0.1
| | |
|
Alcoholism
|
0.28 (0.03–2.43)
|
0.41
| | |
|
Positive cultures
|
0.65 (0.22–1.93)
|
0.59
| | |
|
Pre-hospital antimicrobial therapy
|
2.22 (0.75–6.65)
|
0.18
|
3.10 (0.92–11.7)
|
0.068
|
|
Operation before starting CRRT
|
0.79 (0.24–2.64)
|
0.77
| | |
|
PMX-DHP combination
|
1.78 (0.58–5.41)
|
0.39
| | |
|
AKI at the start of CRRT
|
0.55 (0.17–1.74)
|
0.37
| | |
|
Lactate ≥ 2 mmol/L
|
6.80 (1.74–26.6)
|
0.003*
|
8.16 (2.12–42.8)
|
0.0015*
|
|
Mean blood pressure ≤ 65 mmHg
|
2.38 (0.80–7.09)
|
0.16
| | |
|
Use of catecholamine
|
1.33 (0.37–4.85)
|
0.76
| | |
|
SOFA score ≥ 14
|
6.33 (1.85–21.6)
|
0.0039*
| | |
|
APACHE II score ≥ 36
|
3.18 (1.01–10.0)
|
0.07
| | |
|
Septic shock (Sepsis-3)
|
6.80 (1.74–26.6)
|
0.003*
| | |
|
Septic shock (Sepsis-1)
|
2.18 (0.72–6.57)
|
0.25
| | |
- Values are expressed as median (interquartile range)
- The covariates in the multivariable-adjusted models were age ≥ 65 years, pre-hospital antimicrobial therapy, and lactate ≥ 2 mmol/L
- Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B-immobilized fiber column direct hemoperfusion, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation
- *P < 0.05
