Effect of bixalomer on coronary artery calcification in hemodialysis patients with hyperphosphatemia: a multi-center, randomized controlled trial

Table 4 Changes in CAC score from baseline to 6 and 12 months (primary endpoint)

	Change in CAC scores at 6 months	P value	Change in CAC scores at 12 months	P value
Bixalomer, N	38		31
Mean ± SD	81.3 ± 136.8	0.001	126.7 ± 154.8	< 0.001
95% CI	36.3, 126.3		69.9, 183.5
Median	49.53		113.53
Minimum/maximum	− 144.39/592.2		− 92.79/653.2
Calcium carbonate, N	35		34
Mean ± SD	125.4 ± 157.2	< 0.001	268.6 ± 320.1	< 0.001
95% CI	71.4, 179.4		157.0, 380.3
Median	59.62		176.92
Minimum/maximum	− 62.69/621.7		− 24.69/1342.2
Difference between groups	− 44.1		− 141.9
95% CI	− 112.8, 24.5		− 268.5, − 15.3
P value^a	0.204		0.029

^aChanges from baseline over time were compared between groups using the paired t test
Abbreviations: CAC coronary artery calcium, CI confidence interval, N number of patients, SD standard deviation

ISSN: 2059-1381