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Table 4 Changes in CAC score from baseline to 6 and 12 months (primary endpoint)

From: Effect of bixalomer on coronary artery calcification in hemodialysis patients with hyperphosphatemia: a multi-center, randomized controlled trial

  Change in CAC scores at 6 months P value Change in CAC scores at 12 months P value
Bixalomer, N 38   31  
 Mean ± SD 81.3 ± 136.8 0.001 126.7 ± 154.8 < 0.001
 95% CI 36.3, 126.3 69.9, 183.5
 Median 49.53 113.53
 Minimum/maximum − 144.39/592.2 − 92.79/653.2
Calcium carbonate, N 35   34  
 Mean ± SD 125.4 ± 157.2 < 0.001 268.6 ± 320.1 < 0.001
 95% CI 71.4, 179.4 157.0, 380.3
 Median 59.62 176.92
 Minimum/maximum − 62.69/621.7 − 24.69/1342.2
Difference between groups − 44.1   − 141.9  
 95% CI − 112.8, 24.5 − 268.5, − 15.3
P valuea 0.204 0.029
  1. aChanges from baseline over time were compared between groups using the paired t test
  2. Abbreviations: CAC coronary artery calcium, CI confidence interval, N number of patients, SD standard deviation