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Table 5 Phosphate, calcium, and intact PTH levels throughout the study period

From: Effect of bixalomer on coronary artery calcification in hemodialysis patients with hyperphosphatemia: a multi-center, randomized controlled trial

  Baseline 3 months 6 months 12 months
Phosphate, mg/dL
 Bixalomer, N 43 38 38 31
  Mean ± SD 5.32 ± 1.23 5.87 ± 1.15 5.73 ± 1.29 5.65 ± 1.14
  95% CI 4.94, 5.70 5.50, 6.25 5.31, 6.16 5.23, 6.06
  Median 5.3 5.8 5.8 5.7
  Minimum/maximum 2.8/8.0 3.7/8.7 2.5/8.9 3.7/8.3
 Calcium carbonate, N 40 38 36 35
  Mean ± SD 5.32 ± 1.10 4.95 ± 1.33 5.13 ± 1.06 4.93 ± 1.18
  95% CI 4.96, 5.67 4.51, 5.39 4.77, 5.48 4.53, 5.34
  Median 5.2 5.1 5.1 5.0
  Minimum/maximum 3.3/7.8 2.1/8.1 2.4/7.2 2.8/7.6
 Difference between groups, Mean 0.01 0.93 0.61 0.71
  95% CI − 0.51, 0.52 0.36, 1.50 0.06, 1.16 0.14, 1.29
  P valuea 0.982 0.002 0.030 0.015
Calcium, mg/dL
 Bixalomer, N 43 38 38 31
  Mean ± SD 9.15 ± 0.70 8.89 ± 0.49 8.91 ± 0.62 8.85 ± 0.56
  95% CI 8.94, 9.37 8.73, 9.05 8.70, 9.11 8.64, 9.05
  Median 9.1 9.0 8.9 8.9
  Minimum/maximum 8.3/11.8 7.8/10.1 7.5/10.1 7.6/9.7
 Calcium carbonate, N 40 38 36 35
  Mean ± SD 9.05 ± 0.75 9.16 ± 0.72 9.23 ± 0.72 9.33 ± 0.75
  95% CI 8.81, 9.28 8.92, 9.39 8.99, 9.48 9.07, 9.59
  Median 9.0 9.1 9.1 9.4
  Minimum/maximum 7.0/11.2 7.8/10.9 8.0/11.5 7.9/10.6
 Difference between groups, Mean 0.11 − 0.26 − 0.33 − 0.49
  95% CI − 0.21, 0.42 − 0.54, 0.02 − 0.64, − 0.02 − 0.82, − 0.16
  P valuea 0.505 0.065 0.040 0.004
Intact PTH, pg/mL
 Bixalomer, N 40 35 36 31
  Mean ± SD 173.0 ± 102.6 200.1 ± 98.2 208.4 ± 96.7 192.2 ± 95.0
  95% CI 140.2, 205.9 166.4, 233.8 175.7, 241.2 157.4, 227.1
  Median 149 208 184.5 180
 Minimum/maximum 11/395 7/423 47/382 9/393
 Calcium carbonate, N 38 35 32 34
  Mean ± SD 134.4 ± 83.7 120.9 ± 84.9 163.1 ± 107.8 141.4 ± 91.4
  95% CI 106.9, 161.9 91.7, 150.0 124.2, 201.9 109.4, 173.3
  Median 127.5 121 158 125.5
  Minimum/maximum 5/376 2/311 8/460 9/358
 Difference between groups, Mean 38.6 79.2 45.4 50.9
  95% CI − 3.7, 81.0 35.5, 123.0 − 4.1, 94.9 4.7, 97.1
  P valuea 0.073 0.001 0.072 0.032
  1. aComparisons between groups were conducted using t test
  2. Abbreviations: CI confidence interval, N number of patients, PTH parathyroid hormone, SD standard deviation