Table 5 Phosphate, calcium, and intact PTH levels throughout the study period

 Bixalomer, N

43

38

38

31

  Mean ± SD

5.32 ± 1.23

5.87 ± 1.15

5.73 ± 1.29

5.65 ± 1.14

  95% CI

4.94, 5.70

5.50, 6.25

5.31, 6.16

5.23, 6.06

  Median

5.3

5.8

5.8

5.7

  Minimum/maximum

2.8/8.0

3.7/8.7

2.5/8.9

3.7/8.3

 Calcium carbonate, N

40

38

36

35

  Mean ± SD

5.32 ± 1.10

4.95 ± 1.33

5.13 ± 1.06

4.93 ± 1.18

  95% CI

4.96, 5.67

4.51, 5.39

4.77, 5.48

4.53, 5.34

  Median

5.2

5.1

5.1

5.0

  Minimum/maximum

3.3/7.8

2.1/8.1

2.4/7.2

2.8/7.6

 Difference between groups, Mean

0.01

0.93

0.61

0.71

  95% CI

− 0.51, 0.52

0.36, 1.50

0.06, 1.16

0.14, 1.29

  P value^a

0.982

0.002

0.030

0.015

 Bixalomer, N

43

38

38

31

  Mean ± SD

9.15 ± 0.70

8.89 ± 0.49

8.91 ± 0.62

8.85 ± 0.56

  95% CI

8.94, 9.37

8.73, 9.05

8.70, 9.11

8.64, 9.05

  Median

9.1

9.0

8.9

8.9

  Minimum/maximum

8.3/11.8

7.8/10.1

7.5/10.1

7.6/9.7

 Calcium carbonate, N

40

38

36

35

  Mean ± SD

9.05 ± 0.75

9.16 ± 0.72

9.23 ± 0.72

9.33 ± 0.75

  95% CI

8.81, 9.28

8.92, 9.39

8.99, 9.48

9.07, 9.59

  Median

9.0

9.1

9.1

9.4

  Minimum/maximum

7.0/11.2

7.8/10.9

8.0/11.5

7.9/10.6

 Difference between groups, Mean

0.11

− 0.26

− 0.33

− 0.49

  95% CI

− 0.21, 0.42

− 0.54, 0.02

− 0.64, − 0.02

− 0.82, − 0.16

  P value^a

0.505

0.065

0.040

0.004

 Bixalomer, N

40

35

36

31

  Mean ± SD

173.0 ± 102.6

200.1 ± 98.2

208.4 ± 96.7

192.2 ± 95.0

  95% CI

140.2, 205.9

166.4, 233.8

175.7, 241.2

157.4, 227.1

  Median

149

208

184.5

180

 Minimum/maximum

11/395

7/423

47/382

9/393

 Calcium carbonate, N

38

35

32

34

  Mean ± SD

134.4 ± 83.7

120.9 ± 84.9

163.1 ± 107.8

141.4 ± 91.4

  95% CI

106.9, 161.9

91.7, 150.0

124.2, 201.9

109.4, 173.3

  Median

127.5

121

158

125.5

  Minimum/maximum

5/376

2/311

8/460

9/358

 Difference between groups, Mean

38.6

79.2

45.4

50.9

  95% CI

− 3.7, 81.0

35.5, 123.0

− 4.1, 94.9

4.7, 97.1

  P value^a

0.073

0.001

0.072

0.032