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Table 1 Demographic, laboratory, and clinical characteristics

From: Association between serum ferritin levels and clinical outcomes in maintenance hemodialysis patients: a retrospective single-center cohort study

 

Total (n = 116)

LF (n = 87)

HF (n = 29)

p value

Serum ferritin, ng/mL

50.7 (17.5–98.8)

30 (14.3–56.7)

151 (117.5–218)

 

Cohort time, day

1825 (819–1825)

1825 (1008–1825)

1091 (668.5–1825)

 

Age, year

65.4 ± 13.4

64.8 ± 13.5

66.9 ± 13.3

0.47

Malea

81 (70%)

59 (68%)

22 (76%)

0.49

Cause of ESRD

 Diabetic nephropathy

34 (29%)

26 (30%)

8 (28%)

 

 IgA nephropathy or chronic glomerulonephritis

36 (31%)

25 (29%)

11 (38%)

 

 Nephrosclerosis

12 (10%)

10 (11%)

2 (6.9%)

 

 Rapid progressive glomerulonephritis

1 (0.9%)

1 (1.1%)

0 (0%)

 

 Polycystic kidney disease

7 (6.0%)

6 (6.9%)

1 (3.4%)

 

 Others

14 (12%)

10 (11%)

4 (14%)

 

 Unknown

12 (10%)

9 (10%)

3 (10%)

 

Hemoglobin, g/dL

10.8 ± 1.15

10.9 ± 1.08

10.7 ± 1.34

0.49

Serum iron, μg/dL

55.5 (38–73)

54 (35–73)

56 (45–79.5)

0.12

TIBC, μg/dL

271 (235–309)

284 (251–318)

234 (207–257)

< 0.001

T-SAT, %

20.4 (14.8–27.3)

17.9 (13.3–24.6)

25.7 (19.7–34)

0.0007

Intravenous irona

27 (23%)

21 (24%)

6 (21%)

0.80

Iron dose, mg/month

42.1 ± 85.8

45.5 ± 92.1

31.7 ± 63.6

0.46

ESAa

100 (86%)

75 (86%)

25 (86%)

1.00

ESA dose, μg/week

29.9 ± 25.1

30.2 ± 24.7

29.3 ± 26.7

0.87

HD vintage, month

79 (32–136)

81 (33–138)

78 (27–124)

0.68

Kt/V (single pool)

1.40 (1.23–1.54)

1.38 (1.25–1.53)

1.43 (1.21–1.56)

0.067

Serum creatinine, mg/dL

11.9 ± 3.04

12.0 ± 3.16

11.5 ± 2.66

0.43

BUN, mg/dL

64.9 ± 16.0

64.7 ± 15.6

65.5 ± 17.3

0.83

Serum calciumb, mg/dL

9.33 ± 0.67

9.33 ± 0.67

9.35 ± 0.70

0.87

Serum phosphate, mg/dL

5.3 (4.73–5.3)

5.4 (4.9–6.3)

5.0 (4.0–5.45)

0.001

BMI, kg/m2

21.6 ± 3.50

21.8 ± 3.28

21.4 ± 4.07

0.25

Serum albumin, g/dL

3.95 (3.72–4.10)

4.0 (3.8–4.1)

3.9 (3.65–4.1)

0.22

LDL-cholesterol, mg/dL

75 (57.3–94.5)

73 (57–93)

77 (60.5–99)

0.69

CRP, mg/dl

0.07 (0–0.35)

0.05 (0–0.14)

0.30 (0.02–0.77)

0.003

History of CADa

31 (27%)

22 (25%)

9 (31%)

0.63

History of atrial fibrillationa

14 (12%)

10 (11%)

4 (14%)

0.22

History of diabetes mellitus

38 (33%)

28 (32%)

10 (34%)

0.82

History of hypertensiona

100 (86%)

73 (84%)

27 (93%)

0.35

History of dyslipidemiaa

27 (23%)

20 (23%)

7 (24%)

1.00

History of CV events

48 (41%)

34 (39%)

14 (48%)

0.38

History of gastrectomya

6 (5.2%)

3 (3.4%)

3 (10%)

0.16

History of malignancya

5 (4.3%)

4 (4.6%)

1 (3.5%)

0.34

Positive fecal occult blooda

19 (16%)

12 (16%)

7 (25%)

0.39

History of liver disordersa

14 (12%)

10 (12%)

4 (14%)

0.75

Recent hospitalizationa

8 (6.9%)

4 (4.6%)

4 (14%)

0.11

  1. Values are reported as mean ± standard deviation, median (interquartile range) or number (%) as appropriate. Comparisons were made between the two stratified populations
  2. LF low-ferritin, HF high-ferritin, ESRD end-stage renal disease, TIBC total iron binding capacity, T-SAT total iron binding capacity, ESA erythropoietin-stimulating agent, HD hemodialysis, BMI body mass index, CRP C-reactive protein, CAD coronary artery disease, CV cardiovascular
  3. aAnalyzed by Fisher’s exact test
  4. bCorrected using the following formula: Corrected calcium = serum calcium + (4 − serum albumin) (g/dL) when the albumin level is < 4 g/dL