| |
PMX-DHP-2 h (n = 7)
|
PMX-DHP-12 h (n = 16)
|
P value
|
|---|
|
Serum lactate concentration, mmol/l
| | |
0.53
|
|
0 h (baseline), N
|
7
|
16
| |
|
median (IQR)
|
4.3 (1.3–6.0)
|
2.9 (1.3–6.7)
| |
|
2 h, N
|
7
|
16
| |
|
median (IQR)
|
2.9 (1.4–6.1)
|
3.2 (1.7–6.0)
| |
|
5 h, N
|
6
|
14
| |
|
median (IQR)
|
2.0 (1.5–6.2)
|
2.6 (1.6–4.0)
| |
|
8 h, N
|
7
|
15
| |
|
median (IQR)
|
1.8 (1.6–4.0)
|
2.9 (1.9–3.6)
| |
|
12 h, N
|
7
|
14
| |
|
median (IQR)
|
1.5 (1.2–2.7)
|
2.6 (1.7–3.7)
| |
|
PaO2/FiO2 ratio
| | |
0.53
|
|
0 h (baseline), N
|
7
|
15
| |
|
mean ± SD
|
278 ± 138
|
260 ± 128
| |
|
2 h, N
|
7
|
15
| |
|
mean ± SD
|
287 ± 108
|
279 ± 124
| |
|
5 h, N
|
6
|
13
| |
|
mean ± SD
|
329 ± 109
|
283 ± 120
| |
|
8 h, N
|
7
|
14
| |
|
mean ± SD
|
310 ± 124
|
289 ± 108
| |
|
12 h, N
|
7
|
14
| |
|
mean ± SD
|
318 ± 94
|
281 ± 109
| |
- The two groups were compared using a two-way repeated measurements analysis of variance. Serum lactate and PaO2/FiO2 were measured just before starting PMX-DHP administration (0 h). Serum lactate concentration was transformed into the natural logarithm before it was included in the analysis
- PMX-DHP-2h polymyxin direct hemoperfusion for 2 h, PMX-DHP-12h polymyxin direct hemoperfusion for 12 h, IQR interquartile range, SD standard deviation
