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Table 2 Serum lactate concentration and PaO2/FiO2 ratio

From: Effects of prolonged direct hemoperfusion using a polymyxin B immobilized fiber cartridge on interleukin-6 concentration in patients with septic shock: a prospective exploratory trial

 

PMX-DHP-2 h (n = 7)

PMX-DHP-12 h (n = 16)

P value

Serum lactate concentration, mmol/l

  

0.53

 0 h (baseline), N

7

16

 

 median (IQR)

4.3 (1.3–6.0)

2.9 (1.3–6.7)

 

 2 h, N

7

16

 

 median (IQR)

2.9 (1.4–6.1)

3.2 (1.7–6.0)

 

 5 h, N

6

14

 

 median (IQR)

2.0 (1.5–6.2)

2.6 (1.6–4.0)

 

 8 h, N

7

15

 

 median (IQR)

1.8 (1.6–4.0)

2.9 (1.9–3.6)

 

 12 h, N

7

14

 

 median (IQR)

1.5 (1.2–2.7)

2.6 (1.7–3.7)

 

PaO2/FiO2 ratio

  

0.53

 0 h (baseline), N

7

15

 

 mean ± SD

278 ± 138

260 ± 128

 

 2 h, N

7

15

 

 mean ± SD

287 ± 108

279 ± 124

 

 5 h, N

6

13

 

 mean ± SD

329 ± 109

283 ± 120

 

 8 h, N

7

14

 

 mean ± SD

310 ± 124

289 ± 108

 

 12 h, N

7

14

 

 mean ± SD

318 ± 94

281 ± 109

 
  1. The two groups were compared using a two-way repeated measurements analysis of variance. Serum lactate and PaO2/FiO2 were measured just before starting PMX-DHP administration (0 h). Serum lactate concentration was transformed into the natural logarithm before it was included in the analysis
  2. PMX-DHP-2h polymyxin direct hemoperfusion for 2 h, PMX-DHP-12h polymyxin direct hemoperfusion for 12 h, IQR interquartile range, SD standard deviation