|
Types of AEs
|
Disease stage
|
Rate of increase in hemoglobin level immediately before onset of AEs (g/dL/week)
|
|---|
|
<− 0.5
|
≥ − 0.5 and < − 0.3
|
≥ − 0.3 and ≤ 0.3
|
> 0.3 and ≤ 0.5
|
> 0.5
|
|---|
|
Overall patients
|
ND
|
161
|
370
|
1522
|
477
|
212
|
|
HD
|
155
|
419
|
1367
|
423
|
119
|
|
PD
|
43
|
138
|
330
|
153
|
71
|
|
All AEs
|
ND
|
7 (4.34)
|
3 (0.81)
|
48 (3.15)
|
2 (0.41)
|
2 (0.94)
|
|
HD
|
1 (0.64)
|
2 (0.47)
|
64 (4.68)
|
7 (1.65)
|
1 (0.84)
|
|
PD
|
1 (2.32)
|
3 (2.17)
|
14 (4.24)
|
2 (1.30)
|
0 (0.00)
|
|
Vascular access thrombosis
|
ND
|
–
|
–
|
1 (0.06)
|
–
|
–
|
|
HD
|
–
|
1 (0.23)
|
8 (0.58)
|
1 (0.23)
|
–
|
|
PD
|
–
|
–
|
–
|
–
|
–
|
|
Hypertension
|
ND
|
–
|
–
|
21 (1.37)
|
–
|
1 (0.47)
|
|
HD
|
–
|
1 (0.23)
|
28 (2.04)
|
1 (0.23)
|
–
|
|
PD
|
–
|
2 (1.44)
|
8 (2.42)
|
2 (1.30)
|
–
|
|
Cardiovascular disease
|
ND
|
4 (2.48)
|
2 (0.54)
|
21 (1.37)
|
2 (0.41)
|
1 (0.47)
|
|
HD
|
1 (0.64)
|
–
|
15 (1.09)
|
2 (0.47)
|
1 (0.84)
|
|
PD
|
–
|
1 (0.72)
|
6 (1.81)
|
–
|
–
|
|
Cerebral hemorrhage
|
ND
|
1 (0.62)
|
1 (0.27)
|
3 (0.19)
|
–
|
–
|
|
HD
|
–
|
–
|
7 (0.51)
|
2 (0.47)
|
–
|
|
PD
|
–
|
–
|
1 (0.30)
|
–
|
–
|
|
Thromboembolism
|
ND
|
2 (1.24)
|
–
|
5 (0.32)
|
–
|
–
|
|
HD
|
–
|
1 (0.23)
|
22 (1.60)
|
3 (0.70)
|
–
|
|
PD
|
1 (2.32)
|
–
|
1 (0.30)
|
–
|
–
|
- AEs adverse events, Hb hemoglobin, HD hemodialysis, ND not on dialysis, PD peritoneal dialysis
