Table 4 Summary of findings
Peritoneal dialysis compared to hemodialysis for first renal replacement therapy in end-stage renal disease patients with diabetes | |||
Patient or population: end-stage renal disease patients with diabetes considering renal replacement therapy Setting: all settings Intervention: peritoneal dialysis Comparison: hemodialysis | |||
Outcomes | Impact | No. of participants (studies) | Certainty of the evidence (GRADE) |
New-onset cardiovascular disease | Two studies investigated new-onset cardiovascular disease among diabetic patients undergoing PD and HD. The differences in incidence favored HD in both studies. | 22,656 (2 observational studies) | ⨁◯◯◯ Very lowa,b |
New-onset infectious disease—not reported | – | – | |
Residual renal function—not reported | – | – | |
Glycemic control—not reported | – | – | |
*Risk in the intervention group (and 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and 95% CI). CI: confidence interval | |||
GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: We are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate. The true effect is likely to be substantially different from the estimate of effect. | |||