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Table 2 Summary of findings

From: Comparison of clinical effects between icodextrin and glucose solutions on outcomes of peritoneal dialysis: systematic review and meta-analysis of randomized controlled trials

Icodextrin versus glucose-based solution for patients receiving peritoneal dialysis
Patient or population: patients receiving peritoneal dialysis
Setting: community
Intervention: icodextrin
Comparison: glucose-based solution
Outcomes№ of participants
(studies)
Certainty of the evidence
(GRADE)
Relative effect
(95% CI)
Anticipated absolute effects
Risk with glucose-based solutionRisk difference with icodextrin
All-cause mortality1106 (10 RCTs)
LOW
RR 0.75
(0.33 to 1.71)
27 per 10007 fewer per 1000
(18 fewer to 19 more)
Technical survival470 (5 RCTs)
LOW
RR 0.57
(0.29 to 1.12)
74 per 100032 fewer per 1000
(52 fewer to 9 more)
Episodes of uncontrolled fluid overload236 (4 RCTs)
MODERATE
RR 0.31
(0.12 to 0.82)
108 per 100073 fewer per 1000
(93 fewer to 19 fewer)
Peritoneal ultrafiltration252 (6 RCTs)
LOW
 MD 186.76 higher
(47.08 lower to 420.59 higher)
Urine volume136 (4 RCTs)
LOW
 MD 106.08 higher
(173.29 lower to 385.45 higher)
Residual renal function181 (5 RCTs)
MODERATE
 MD 0.56 higher
(0.37 lower to 1.49 higher)
Peritoneal function105 (2 RCTs)
VERY LOW
 MD 0.001 higher
(0.07 lower to 0.07 higher)
Peritonitis1034 (8 RCTs)
LOW
RR 0.95
(0.79 to 1.15)
224 per 100011 fewer per 1000
(47 fewer to 34 more)
Rash855 (4 RCTs)
LOW
RR 1.84
(0.48 to 7.09)
51 per 100043 more per 1000
(26 fewer to 310 more)
  1. *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI Confidence interval, RR Risk ratio, MD Mean difference