Table 2 Summary of findings
| Icodextrin versus glucose-based solution for patients receiving peritoneal dialysis | |||||
|---|---|---|---|---|---|
| Patient or population: patients receiving peritoneal dialysis | |||||
| Setting: community | |||||
| Intervention: icodextrin | |||||
| Comparison: glucose-based solution | |||||
| Outcomes | № of participants (studies) | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
| Risk with glucose-based solution | Risk difference with icodextrin | ||||
| All-cause mortality | 1106 (10 RCTs) | ⨁⨁◯◯ LOW | RR 0.75 (0.33 to 1.71) | 27 per 1000 | 7 fewer per 1000 (18 fewer to 19 more) |
| Technical survival | 470 (5 RCTs) | ⨁⨁◯◯ LOW | RR 0.57 (0.29 to 1.12) | 74 per 1000 | 32 fewer per 1000 (52 fewer to 9 more) |
| Episodes of uncontrolled fluid overload | 236 (4 RCTs) | ⨁⨁⨁◯ MODERATE | RR 0.31 (0.12 to 0.82) | 108 per 1000 | 73 fewer per 1000 (93 fewer to 19 fewer) |
| Peritoneal ultrafiltration | 252 (6 RCTs) | ⨁⨁◯◯ LOW | – | MD 186.76 higher (47.08 lower to 420.59 higher) | |
| Urine volume | 136 (4 RCTs) | ⨁⨁◯◯ LOW | – | MD 106.08 higher (173.29 lower to 385.45 higher) | |
| Residual renal function | 181 (5 RCTs) | ⨁⨁⨁◯ MODERATE | – | MD 0.56 higher (0.37 lower to 1.49 higher) | |
| Peritoneal function | 105 (2 RCTs) | ⨁◯◯◯ VERY LOW | – | MD 0.001 higher (0.07 lower to 0.07 higher) | |
| Peritonitis | 1034 (8 RCTs) | ⨁⨁◯◯ LOW | RR 0.95 (0.79 to 1.15) | 224 per 1000 | 11 fewer per 1000 (47 fewer to 34 more) |
| Rash | 855 (4 RCTs) | ⨁⨁◯◯ LOW | RR 1.84 (0.48 to 7.09) | 51 per 1000 | 43 more per 1000 (26 fewer to 310 more) |