Efficacy and safety of elobixibat in hemodialysis patients with chronic constipation: a retrospective study

Table 3 Comparison of spontaneous stool frequency and constipation score by clinical history

Parameter	Current medical history	Mean ± SD		p value
Parameter	Current medical history	Baseline	Week 12 after administration	p value
Spontaneous stool frequency	Diabetic nephropathy	1.8 ± 0.5	4.9 ± 2.4	0.009
Spontaneous stool frequency	Others	2.2 ± 0.9	5.0 ± 2.4	< 0.001
Total CSS score	Diabetic nephropathy	10.6 ± 3.6	6.8 ± 4.3	0.014
Total CSS score	Others	10.3 ± 2.9	5.0 ± 2.1	0.006
Stool frequency	Diabetic nephropathy	1.1 ± 0.4	0.3 ± 0.5	0.011
Stool frequency	Others	0.8 ± 0.9	0.5 ± 0.7	0.203
Dyschezia	Diabetic nephropathy	1.5 ± 0.8	0.9 ± 1.0	0.120
Dyschezia	Others	2.2 ± 1.0	0.4 ± 0.7	0.003
A sensation of incomplete evacuation	Diabetic nephropathy	2.4 ± 1.3	1.6 ± 1.6	0.095
A sensation of incomplete evacuation	Others	2.0 ± 1.3	1.1 ± 1.2	0.138
Abdominal pain	Diabetic nephropathy	1.4 ± 0.7	0.8 ± 1.4	0.284
Abdominal pain	Others	1.0 ± 1.3	0.3 ± 0.6	0.048
Time to evacuation	Diabetic nephropathy	1.1 ± 0.8	0.8 ± 0.9	0.149
Time to evacuation	Others	0.7 ± 0.6	0.5 ± 0.7	0.530
Assisted bowel movements	Diabetic nephropathy	1.0 ± 0.0	1.0 ± 0.0	†
Assisted bowel movements	Others	1.3 ± 0.5	0.7 ± 0.5	0.020
Number of bowel movements failed/24 h	Diabetic nephropathy	1.0 ± 0.5	0.4 ± 0.5	0.037
Number of bowel movements failed/24 h	Others	1.2 ± 0.4	0.2 ± 0.4	0.003
Duration (years) of suffering from disturbed defecation	Diabetic nephropathy	1.1 ± 0.6	1.1 ± 0.6	―
Duration (years) of suffering from disturbed defecation	Others	1.1 ± 1.0	1.4 ± 1.4	―

Results of analysis: diabetic nephropathy n = 8, others n = 11
Statistical analysis was performed using the paired t-test (spontaneous stool frequency) or Wilcoxon signed-rank test (CSS scores)
No statistical analysis was performed on the duration of suffering from disturbed defecation
†The p value could not be calculated

ISSN: 2059-1381