| Parameter | Use of phosphate binder | Mean ± SD | p value |
|---|
| Baseline | Week 12 after administration |
|---|
| Spontaneous stool frequency | Yes | 1.8 ± 0.6 | 4.9 ± 2.3 | < 0.001 |
| No | 2.6 ± 0.9 | 5.2 ± 2.6 | 0.033 |
| Total CSS score | Yes | 10.1 ± 3.1 | 5.7 ± 2.7 | 0.002 |
| No | 11.2 ± 3.5 | 5.8 ± 4.8 | 0.058 |
| Stool frequency | Yes | 0.8 ± 0.6 | 0.4 ± 0.6 | 0.041 |
| No | 1.4 ± 0.9 | 0.4 ± 0.5 | 0.089 |
| Dyschezia | Yes | 1.8 ± 1.0 | 0.5 ± 0.7 | 0.002 |
| No | 2.2 ± 0.8 | 0.8 ± 1.3 | 0.134 |
| A sensation of incomplete evacuation | Yes | 2.2 ± 1.3 | 1.3 ± 1.4 | 0.091 |
| No | 2.0 ± 1.2 | 1.4 ± 1.5 | 0.149 |
| Abdominal pain | Yes | 1.3 ± 1.1 | 0.6 ± 1.2 | 0.101 |
| No | 0.8 ± 0.8 | 0.2 ± 0.4 | 0.149 |
| Time to evacuation | Yes | 0.9 ± 0.8 | 0.6 ± 0.6 | 0.182 |
| No | 1.0 ± 0.7 | 0.8 ± 1.1 | 0.773 |
| Assisted bowel movements | Yes | 1.1 ± 0.4 | 0.9 ± 0.3 | 0.149 |
| No | 1.2 ± 0.4 | 0.6 ± 0.5 | 0.149 |
| Number of bowel movements failed/24 h | Yes | 1.1 ± 0.5 | 0.3 ± 0.5 | 0.002 |
| No | 1.0 ± 0.0 | 0.2 ± 0.4 | 0.072 |
| Duration (years) of suffering from disturbed defecation | Yes | 0.9 ± 0.5 | 1.2 ± 1.0 | ― |
| No | 1.6 ± 1.5 | 1.4 ± 1.7 | ― |
- Results of analysis: patients with phosphate binder treatment n = 14, patients without phosphate binder treatment n = 5
- Statistical analysis was performed using the paired t-test (spontaneous stool frequency) or Wilcoxon signed-rank test (CSS scores)
- No statistical analysis was performed on the duration of suffering from disturbed defecation
