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Table 2 Literature review of patients with ICI-related TMA/TTP

From: Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review

References Age Sex Malignancy Agents irAE Days since last administration of ICI Treatment Outcome
Cortazar et al. [3] 58 M Melanoma Ipilimumab TMA 7 Steroids, HD Dialysis-dependent
King et al. [14] 68 F Melanoma Ipilimumab TTP 22 Steroids, PE, IVIG, RTX Recovered
Youssef et al. [12] 42 F Renal cell carcinoma Nivolumab + Ipilimumab TTP 9 Steroids, PE Recovered
Honjo et al. [15] 52 F Pleomorphic carcinoma of lung Nivolumab TTP 14 Steroids, MMF, CHDF Recovered
Lafranchi et al. [13] 70 M Melanoma Nivolumab + Ipilimumab TTP 18 Steroids, PE Died
Hayata et al. (This case) 68 M Urothelial cancer Pembrolizumab TMA 21 Steroids, PE, HD Died
  1. IVIG intravenous immunoglobulin, RTX rituximab, CHDF continuous hemodiafiltration