Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review

Table 2 Literature review of patients with ICI-related TMA/TTP

References	Age	Sex	Malignancy	Agents	irAE	Days since last administration of ICI	Treatment	Outcome
Cortazar et al. [3]	58	M	Melanoma	Ipilimumab	TMA	7	Steroids, HD	Dialysis-dependent
King et al. [14]	68	F	Melanoma	Ipilimumab	TTP	22	Steroids, PE, IVIG, RTX	Recovered
Youssef et al. [12]	42	F	Renal cell carcinoma	Nivolumab + Ipilimumab	TTP	9	Steroids, PE	Recovered
Honjo et al. [15]	52	F	Pleomorphic carcinoma of lung	Nivolumab	TTP	14	Steroids, MMF, CHDF	Recovered
Lafranchi et al. [13]	70	M	Melanoma	Nivolumab + Ipilimumab	TTP	18	Steroids, PE	Died
Hayata et al. (This case)	68	M	Urothelial cancer	Pembrolizumab	TMA	21	Steroids, PE, HD	Died

IVIG intravenous immunoglobulin, RTX rituximab, CHDF continuous hemodiafiltration

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