Outcome | Vitamin C arm (n = 9) | Placebo arm (n = 10) | P |
---|---|---|---|
Primary | |||
DGFa, dialysis criteria, n (%) | 1 (11.1) | 1 (10.0) | > 0.99 |
DGFa, urine output criteria, n (%) | 1 (11.1) | 2 (20.0) | > 0.99 |
DGFa, Scr trend criteria, n (%) | 2 (22.2) | 2 (20.0) | > 0.99 |
DGF, any criteria, n (%) | 3 (33.3) | 3 (30.0) | > 0.99 |
DGF duration (days) | 7.33 ± 5.68 | 19.66 ± 0.57 | 0.02 |
eGFRb at discharge (ml/min/1.73m2) | 55.80 ± 21.14 | 52.02 ± 11.71 | 0.63 |
eGFR 1 month after transplantation (ml/min/1.73m2) | 52.0 (18.9-84.4) | 47.2 (36.0-85.5) | 0.71 |
eGFR 2 months after transplantation (ml/min/1.73m2) | 46.05 ± 16.2 | 60.6 ± 16.6 | 0.08 |
eGFR 3 months after transplantation (ml/min/1.73m2) | 55.75 ± 18.23 | 60.01 ± 16.49 | 0.30 |
SCrc at discharge (mg/dL) | 1.3 (1.1-3) | 1.4 (1-2.1) | 0.56 |
SCr 1 month after transplantation (mg/dL) | 1.6 (1.0-2.9) | 1.3 (0.8-1.9) | 0.34 |
SCr 2 months after transplantation (mg/dL) | 1.7 (1.2-2.8) | 1.22 (0.8-1.6) | 0.009 |
SCr 3 months after transplantation (mg/dL) | 1.40 (1.1-3.08) | 1.13 (0.9-2) | 0.07 |
Secondary | |||
Hospitalization duration (days) | 14 (9-48) | 18 (8-32) | 0.87 |
Total acute rejection, n (%) | 6 (66.6) | 4 (40.0) | 0.37 |
AMRd, n (%) | 2 (22.2) | 2 (20.0) | > 0.99 |
TCMRe, n (%) | 2 (22.2) | 2 (20.0) | > 0.99 |
Mixed rejection episode, n (%) | 2 (22.2) | 0 | 0.21 |
Time to first rejection (days) | 10 (5-72) | 11.5 (5-18) | 0.78 |