Table 3 Case reports of neonatal and pediatric patients with septic shock treated with PMX-DHP or CRRT with AN69ST since 2010
No. | First author [ref. no.] | Year | Age/sex | Body weight | Diagnosis | Microorganism | Mode of CRRT | Serum IL-6 (pg/mL) | Hospital mortality | |
|---|---|---|---|---|---|---|---|---|---|---|
Before treatment | After treatment | |||||||||
1 | Hirabayashi [7] | 2010 | 15 y/M | No data | ALL, MOF | Bacillus cereus | PMX-DHP + CHDF | 31,500 | Normal level | Survived |
2 | Koga [8] | 2013 | 3 y/M | 12 kg | Germ cell tumor | Enterobacter cloacae | PMX-DHP | No data | No data | Survived |
3 | Tokumasu [9] | 2015 | 1 day/F | 1236 g | EOS | Streptococcus pneumoniae | PMX-DHP + CHDF | 9770 | 15.9 | Survived |
4 | Nishizaki [10] | 2015 | 1 day/M | 601 g | EOS | ESBL-E. coli | PMX-DHP | > 5000 | < 1000 | Survived |
5 | Nanishi [11] | 2016 | 15 y/M | 56.2 kg | TSS | Staphylococcus aureus | PMX-DHP | 387 | 192 | Survived |
6 | Nishizaki [12] | 2017 | 1 day/F | 861 g | EOS | Enterbacto cloacae | PMX-DHP | > 5000 | < 1000 | Survived |
7 | Nishizaki [12] | 2017 | 1 day/F | 788 g | EOS | Streptococcus agalactiae | PMX-DHP | 6792 | 73 | Survived |
8 | Kaneda [13] | 2017 | 1 y/M | 13 kg | HUS | Enterohemorrhagic E. coli O111 | PMX-DHP + CHDF | 142 | 5 | Survived |
9 | Kim [14] | 2019 | 7 days/F | 3.0 kg | LOS | Acinetobacter baumannii | PMX-DHP + ECMO | No data | No data | Died |
10 | Hara [15] | 2020 | 1 day/M | 2848 g | EOS | Cytomegalovirus | PMX-DHP | > 5000 | No data | Survived |
11 | Present case | 2020 | 3 m/F | 4.2 kg | LOS, AKI | Not detected | CHD with AN69ST | 315,000 | 1080 | Died |