Fig. 2
From: A new insight into the treatment of renal anemia with HIF stabilizer
“Iron sequestration in the cells” (a) and “hematopoietic action of HIF stabilizers” (b). As a result of the HIF-PHD inhibition with HIF stabilizers, HIF induces endogenous EPO and facilitates RBC production in the bone marrow. HIF also induces genes related to iron mobilization for effective erythropoiesis. Serum hepcidin levels are increased in CKD patients, and HIF inhibits hepcidin through the stimulation of erythroferrone (ERFE) to accelerate erythropoiesis. FPN ferroportin, DMT-1 divalent metal transporter-1, TfR transferrin receptor. Quoted from reference # 46