A new insight into the treatment of renal anemia with HIF stabilizer

Table 2 Positive indications and conditions requiring clinical consideration (opinion-based recommendations of HIF stabilizers)

Positive indications
1. ESA resistance or unresponsiveness 2. Cardio-renal protection in CRA syndrome 3. Iron mobilization in the condition akin to MIA syndrome
Consideration required
1. Thrombosis and/or embolism 2. Malignancy and retinopathy 3. Pulmonary hypertension 4. ADPKD 5. Pregnancy or desire to bear children 6. Hyperkalemia, liver dysfunction

Note:The adverse effects of ESA are already well known; however, those of HIF stabilizers have not always been clarified clinically. The adverse effects with HIF stabilizers include expanded interpretations of the ESA-based findings and/or the inferences based on animal experiments
ESA erythropoiesis stimulating agent, MIA malnutrition-inflammation-atherosclerosis, CRA cardiovascular-renal-anemia, ADPKD autosomal dominant polycystic kidney disease

ISSN: 2059-1381