Fig. 1

Schematic presentation of URAT1 (SLC22A12). URAT1 belongs to the organic ion transporter family (SLC22). URAT1 consists of 555 amino acid residues and 12 predicted putative transmembrane domains (TMs) with large hydrophilic loops between the first and second as well as six and seventh TMs and intracellular NH2 and COOH terminals with a PDZ binding motif at its end. There are several PKC and PKA phosphorylation sites in transporter